新生儿败血症的免疫及辅助治疗进展

尽管有合理的抗生素治疗,新生儿败血症发病率和病死率仍很高.免疫及辅助疗法已成为能减少新生儿败血症发病率和病死率的一种有效治疗方法.该文对新生儿败血症时应用静脉注射免疫球蛋白、集落刺激因子、微生态制剂、谷氨酰胺、重组人蛋白C、乳铁蛋白和黄嘌呤衍生物等的最新临床试验进行综述.

Adjuvant immunotherapy in neonatal sepsis: advances in treatment

Systemic infections in newborns cause significant morbidity and mortality in spite of appropriate antimicrobial therapy. Consequently, Immune and adjuvant therapy has emerged as a potential adjuvant therapeutic modality to reduce the morbidity and mortality associated with neonatal sepsis. There were many recent trails including a few of animal trails described the use of intravenous immunoglobulin and colony stimulating factors in neonatal sepsis. In addition, the most recent findings describing the use of probiotics, glutamine supplementation, recombinant human protein C, lactoferrin and pentoxifylline in the treatment of neonatal sepsis have been reviewed.