基质金属蛋白酶2、基质金属蛋白酶9与急性肺损伤关系的研究进展

急性肺损伤是由多种肺内外因素如严重创伤、感染、休克、脓毒症和大量输血等原因引起的弥漫性肺实质损伤.各种原因引起一系列炎症细胞在肺内聚集和活化,释放细胞因子、生长因子及其他炎症介质,引起基质金属蛋白酶(MMP)的合成和活化.MMP-2、MMP-9通过破坏基底膜、促进炎症过程中有关细胞的迁移以及细胞外基质重建,在急性肺损伤...

Research progress on relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and acute lung injury

Acute lung injury (ALI) is diffuse pulmonary parenchymal damage caused by various internal and external factors such as severe trauma, infection, shock, sepsis, and massive blood transfusion. Various factors lead to the aggregation and activation of a series of inflammatory cells in the lung, the release of cytokines, growth factors and other inflammatory mediators, which causes the synthesis and activation of matrix metalloproteinase (MMP). MMP-2 and MMP-9 play important roles in the pathogenesis of ALI through destructing the basement membrane, promoting the migration of cells related with inflammatory process and the reconstruction of extracellular matrix. The studies about the mechanism of MMP-2 and MMP-9 in ALI are important for the prevention and treatment of ALI.