| 建立胃癌裸鼠模型的研究进展 |
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| 引用本文： | 张云鹏,孙鹏. 建立胃癌裸鼠模型的研究进展[J]. 国际外科学杂志, 2011, 38(7): 472-474. DOI: 10.3760/cma.j.issn.1673-4203.2011.07.013 |
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| 作者姓名： | 张云鹏 孙鹏 |
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| 作者单位： | 复旦大学附属华山医院普外科,上海,200040 |
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| 摘 要： | 建立动物模型是实验研究的根本.胃癌模型的制作过程包括选择实验动物、胃癌细胞株、移植细胞的数量和肿瘤移植的方式等.各制作步骤要遵循胃癌的发生发展机制,才能更好地模拟人胃癌生长过程.裸鼠先天性免疫缺陷,为我们提供了较佳的胃癌实验动物.细胞株的选择和种植方式对模型的制作也有重要的影响.
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| 关 键 词： | 胃肿瘤 裸鼠 动物模型 |
Establishment of gastric cancer model in nude mice |
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| ZHANG Yun-peng,SUN Peng. Establishment of gastric cancer model in nude mice[J]. International Journal of Surgery, 2011, 38(7): 472-474. DOI: 10.3760/cma.j.issn.1673-4203.2011.07.013 |
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| Authors: | ZHANG Yun-peng SUN Peng |
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| Abstract: | The establishment of animal model is fundamental to the experimental studies. It involves the selection of animals and cell lines, the determination of the number of cells and the option of the ways of transplant. Only when each production step is operated by following the occurrence and the development mechanism of the gastric cancer, can we simulate the process of growth of the gastric cancer in human body.Due to their congenital immune deficiency, the nude mice serve a better choice for the establishment of gastric cancer animal model. Beyond that, the cell lines selection and transplant way option also play important roles. |
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| Keywords: | Stomach neoplasms Mice,nude Animal model |
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