| 细胞凋亡与神经管发育 |
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| 引用本文： | 官臻. 细胞凋亡与神经管发育[J]. 国际儿科学杂志, 2011, 38(4): 407-409. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.030 |
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| 作者姓名： | 官臻 |
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| 作者单位： | 首都儿科研究所生物技术室,北京,100020 |
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| 摘 要： | 在生物体的发育和自稳态的维持中,细胞凋亡起重要作用.细胞凋亡有助于清除发育过程中多余和异常的细胞,以维持细胞增殖和凋亡的动态平衡,保证神经管的正常发育.在神经管发育期间,细胞凋亡容易受自身遗传、母体营养、环境当中理化因素的影响,这些因素可直接或间接干扰凋亡基因的正常表达,使细胞凋亡发生紊乱,打破细胞增殖和凋亡的动态平衡...
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| 关 键 词： | 细胞凋亡 神经管畸形 胚胎发育 致畸因素 基因 |
Progress on the apoptosis and the neural tube defects |
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| GUAN Zhen. Progress on the apoptosis and the neural tube defects[J]. International Journal of Pediatrics, 2011, 38(4): 407-409. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.030 |
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| Authors: | GUAN Zhen |
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| Abstract: | Apoptosis may play an important role in organ development and balance maintenance, which is beneficial to clear away the abnormal cells. Some teratogens may affect the key apoptotic genes expression, including the genetic defects, the nutritional, and the environmental factors, etc. Apoptotic dysfunction would interfere with the bodys normal development and result in deformity. |
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| Keywords: | Apoptosis Neural tube defects Embryonic development Teratogenic factors Genes |
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