补气活血中药联合复方曲安奈德对口腔扁平苔藓患者血清IL-2及TNF水平的影响

目的 观察补气活血中药联合复方曲安奈德对口腔扁平苔藓患者血清白介素2(IL-2)、肿瘤坏死因子(TNF)水平的影响.方法 将43例口腔扁平苔藓患者按随机数字表法分为两组,对照组21例口服泼尼松片,30 mg/d,第2周减为15 mg/d,第3周减至5 mg/d,维持量4～8周,连用2个月.治疗组22例,根据病损的面积在...

Effects of invigorating Qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on interleukin 2 and tumor necrosis factor in patients With oral lichen planus

Objective To observe the effects of invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on the interleukin 2 and tumor necrosis factor in patients with oral lichen planus. Methods 43 patients with oral lichen planus were randomly recurited into two groups by means of random number table.The control group was treated with prednisone orally, 30 mg/d, then reduced to IS mg/d at first two weeks, and further reduced to S mg/d at first three weeks. Maintained the dose for four to eight weeks. While the treatment group was treated with 40 mg compound triamcinolone acetonide at injury area by local injection,which was mixed with 2% lidocaine hydrochloride injection, once a week, continuous therapy for 2 months. Qi regulating and blood activating drugs were also added to the treatment group, with 150ml each time, once a day for 2 months. The clinical symptoms were observed, serum interleukin 2 and tumor necrosis factor were detected before and after the treatment. Results Compared with the control group, serum interleukin 2 and tumor necrosis factor in the treatment group decreased significantly after treatment IL-2 (2.58± 0.32)ug/L, TNF(156.45+13.67)ng/L,P＜0.05]. Serum interleukin 2 and tumor necrosis factor decreased significantly after the treatment in the control group IL-2(5.21±0.53) μg/L, TNF (205.02±15.75) ng/L,P＜ 0.05]. The total effective rate of the treatment group and the control group was 86.4% and 66.7% respectively, there was a significant difference (x2=3.321,P＜0.05).Conclusion Invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on oral lichen planus was better than prednisone.