| 一氧化氮与眼病的关系 |
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| 引用本文： | 崔卉,李根林.一氧化氮与眼病的关系[J].国际眼科纵览,2014,38(6):420-424. |
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| 作者姓名： | 崔卉 李根林 |
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| 作者单位： | 100730,首都医科大学附属北京同仁医院北京同仁眼科中心眼科学与视觉科学北京市重点实验室 |
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| 摘 要： | 一氧化氮（nitric oxide,NO）是近年来眼科疾病的研究热点.其在体内一氧化氮合酶（nitric oxide synthase,NOS）的催化下生成,作为一种小分子介质调节眼部血流.诸多脉络膜视网膜疾病如葡萄膜炎、青光眼、缺血-再灌注损伤、前部缺血性视神经病变、糖尿病视网膜病变以及视网膜色素变性等发病机制中均发现NO的异常,与NO相拮抗的内皮素-1（Endothelin-1,ET-1）也日益受到关注.对NO合成途径的干预有望成为一种新的眼科治疗手段.
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| 关 键 词： | 一氧化氮 一氧化氮合酶 眼疾病 |
Role of nitric oxide in ocular diseases |
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| CUI Hui,LI Gen-lin.Role of nitric oxide in ocular diseases[J].International Review of Opthalmology,2014,38(6):420-424. |
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| Authors: | CUI Hui LI Gen-lin |
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| Institution: | (Beijing Tongren Eye Center, Belting Tongren Hospital, Capital Medical University, Beijing Key Lab. of Ophthalmology ＆ Visual Sciences, Beijing 100730, China) |
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| Abstract: | In recent years it has been recognized that nitric oxide（NO） is a hot spot in research of ocular diseases.As a molecular medium synthesized by nitric oxide synthase （NOS）.NO is involved in the control of ocular blood flow.Abnormalities of NO system have been observed in a variety of ocular diseases including uveitis,glaucoma,retinal ischemic diseases,diabetic retinopathy and retinitis pigmentosa.In addition,its antagonist endothelin-1 （ET-1） also attracts much attention.All these make the nitric oxide pathway an attractive target for therapeutic interventions of ocular diseases. |
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| Keywords: | nitric oxide nitric oxide synthase ocular diseases |
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