盐酸纳络酮治疗重型脑外伤的疗效观察

目的：比较纳络酮在重型脑外伤中的作用及予后的相关性。方法：将收治的重型颅脑外伤68例随机分成两组，其中对照组30例，采用常规综合治疗及手术(称对照组)治疗组38例，在上述治疗基础上加用纳络酮(称治疗组)。结果：治疗组死亡率为31．6％，较对照组有极其显著的差异，中度致残率和恢复良好率52．6％。重度致残率和植物生存率无显著差异。结论：重症脑外伤早期应用纳络酮能明显降低死亡率，中度致残率和恢复良好率有显著提高，重度致残率和植物生存率无显著差异。

Effect of Naloxone Hydrochloride on patients with severe traumatic brain injury

Objective: To investigate the effects of Naloxone on the patients with severe traumatic brain injury and the relatives with the outcome. Method: Sixty-eight patients with severe traumatic brain injury were randomly divided into two groups. Namely experimental group (38 cases) and control group(30 cases). The basic treatment in the two groups were the same which received routine treatments and surgical treatments. The experimental group was taken Naloxone more. Result: After treatment ,the mortality in the experimental group was 31.6%, with significantly different versus the control group. The moderate-deficit-rate and the good-recovery-rate was 52.6%.However, the incidence of severe deficit and the persistent vegetative status was not significantly different between two groups. Conclusion: Taking Naloxone earlier may significantly decreases the mortality on the patients with severe traumatic brain injury, And playing a good role at rate of moderate deficit and good recovery . But there is no significant difference at the incidence of severe deficit and persistent vegetative status between two groups.