Refined PBPK model of aggregate exposure to methyl tertiary-butyl ether |
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| Authors: | Kim David Andersen Melvin E Pleil Joachim D Nylander-French Leena A Prah James D |
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| Affiliation: | Department of Environmental Science and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. kbkim@hsph.harvard.edu |
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| Abstract: | |
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| Keywords: | AB, amount of TBA in blood AE, amount of MTBE in the skin Aexp, exposed surface area AI, amount of MTBE in the small intestines Aoral, oral dose of MTBE AS, amount of MTBE in the stomach AUC, area under the curve BMI, body mass index BW, body weight CAB, concentration of MTBE in arterial blood Cair, air concentration of MTBE CB, concentration of TBA in blood COTBA, concentration of TBA in other tissue CE, concentration of MTBE in the skin CLTBA, concentration of TBA in the liver ClMET1, Phase I clearance ClMET2, Phase II clearance CV, coefficient of variation CVB, concentration of MTBE in venous blood Cwater, water concentration of MTBE GC–MS, gas chromatography–mass spectrometry HT, height IRIS, integrated risk information system kai, rate constant for intestinal absorption kas, rate constant for stomach absorption KM, Michaelis constant Kp, permeability coefficient ksi, rate constant for transfer from stomach to intestine VE, volume of skin Vmax, maximum rate of metabolism MTBE, methyl tertiary-butyl ether NSC, normalized sensitivity coefficient PBMTBE, blood:air partition coefficient for MTBE PBTBA, blood:air partition coefficient for TBA PBPK, physiologically based pharmacokinetic PE, skin:blood partition coefficient PF, fat:air partition coefficient PLTBA, liver:blood partition coefficient for TBA POMTBE, other tissue:blood partition coefficient for MTBE POTBA, other tissue:blood partition coefficient for TBA PR, rapidly perfused tissue:air partition coefficient PS, slowly perfused tissue:air partition coefficient QC, cardiac output QE, blood flow rate to skin QF, blood flow rate to fat QK, blood flow rate to kidney QL, blood flow rate to liver QOMTBE, blood flow rate to other tissue for the MTBE model QOTBA, blood flow rate to other tissue for the TBA model QP, alveolar ventilation rate QR, blood flow rate to rapidly perfused tissue QS, blood flow rate to slowly perfused tissue QSAR, quantitative structure–activity relationship S.D., standard deviation SURFA, total body surface area TBA, tertiary-butyl alcohol VB, volume of blood VE, volume of skin VF, volume of fat VK, volume of kidney VL, volume of liver VO, volume of other tissue VR, volume of rapidly perfused tissue VS, volume of slowly perfused tissue Vwater, volume of water ingested |
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