| 老瓜头生物总碱抗炎作用机制的实验研究 |
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| 引用本文： | 郑萍,戴贵东,杨卫东. 老瓜头生物总碱抗炎作用机制的实验研究[J]. 宁夏医科大学学报, 2006, 28(2): 99-100 |
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| 作者姓名： | 郑萍 戴贵东 杨卫东 |
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| 作者单位： | [1]宁夏医学院药理学教研室,银川750004 [2]宁夏医学院实验动物中心,银川750004 |
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| 摘 要： | 目的研究老瓜头生物总碱对气囊滑膜炎大鼠的抗炎作用机制.方法采用角叉菜胶（Car）25mg/kg制备大鼠气囊滑膜炎模型,分别观察老瓜头生物总碱2、4、8 mg/kg对气囊灌洗液中白细胞数、蛋白含量、肿瘤坏死因子（TNF）及白细胞介素-6（IL-6）含量的影响.结果腹腔注射老瓜头生物总碱后,灌洗液中白细胞数、蛋白含量显著低于致炎组（P＜0.01）,并且灌洗液中TNF及IL-6的含量也低于致炎组（P＜0.05）.结论老 瓜头生物总碱抗炎作用的机制与降低TNF及IL-6的含量有关.
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| 关 键 词： | 老瓜头生物总碱 抗炎作用 |
| 文章编号： | 1005-8486（2006）02-0099-02 |
| 收稿时间： | 2005-09-06 |
| 修稿时间： | 2005-09-06 |
Experimental Study of Total Alkaloid of Cynanchum Komarovii AI. Icjinski on Anti-inflammatory Mechanism |
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| ZHENG Ping,DAI Gui-dong,YANG Wei-dong. Experimental Study of Total Alkaloid of Cynanchum Komarovii AI. Icjinski on Anti-inflammatory Mechanism[J]. Journal of Ningxia Medical College, 2006, 28(2): 99-100 |
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| Authors: | ZHENG Ping DAI Gui-dong YANG Wei-dong |
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| Affiliation: | 1. Department of Pharmacology, Ningxia Med. Co11., Yinchuan 750004; 2. Animal Center of Ningxia Med. Coll., Yinchuan 750004 |
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| Abstract: | Objective To investigate the anti - inflammatory mechanism of Total Alkaloid of Cynanchum Komarovii AI. Icjinski on acute air - pouch inflammatory model in rats. Methods Air - pouch acute inflammatory model of rats was established with carrageenan(Car, 25mg/kg). The effects of Total Alkaloid of Cynanchum Komarovii AI. Icjinski (2, 4, 8mg/kg) on neutrophil (Neu) counts, protein content, tumor necrosis factor (TNF) and interleukin- 6 (IL-6) content in exudates were measured, respectively. Results After intraperi-tioneal injection of Total Alkaloid of Cynanchum Komarovii AI. Icjinski Neu counts, protein content reduced significantly(P < 0.01), and TNF and IL-6 content reduced too(P < 0.05), compared to inflammatory group. Conclusion The anti - inflammatory mechanisms of Total Alkaloid of Cynanchum Komarovii AI. Icjinski is related to the reduction of TNF and IL-6 contents. |
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| Keywords: | TNF IL-6 |
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