阿立哌唑联用西酞普兰治疗难治性抑郁症的临床对照研究

目的：观察阿立哌唑联合西酞普兰治疗难治性抑郁症的疗效及安全性。方法：将符合条件的68例难治性抑郁症患者随机分为2组，分别用阿立哌唑联合西酞普兰治疗和单用西酞普兰治疗，疗程8周，采用HAMD评定疗效和TESS评定不良反应。结果：治疗结束后，2组HAMD评分较治疗前均显著降低（P＜0．01），试验组治疗效果好（P＜0．01）且起效快（P＜0．05）。试验组的不良反应较对照组的不良反应发生率高，但不良反应较轻，患者可以耐受，2组不良反应差异无统计学意义（ P＞0．05）。结论：阿立哌唑联合西酞普兰治疗难治性抑郁的疗效优于单用西酞普兰且起效快安全性高。

A Comparison Analysis on the Efficacy of Citalopram Combine Ariprazole in the Treatment of Refratory Depression

Objective：To explore the efficacy and safety of Citalopram combined with Aripiprazole in fhe treatment of refractory de -pression.Methods：68 patients with refractory depression were randomly assigned into two groups , one group was treated with Citalopram and Ariprazole and the other group with Citalopram alone for 8 weeks .The efficacy and side effects were evaluated with Hamilton Depres-sion Rating Scale ﹙HAMD﹚and Treatment Emergent symptom Scale ﹙TESS﹚.Results：After the treatment , the HAMD scores of both groups are lower than before prominently （P〈0.01）,the efficacy of experimental group is better （P〈;0.01）and faster （P〈0.05）. The rate of the sideeffect of the experimental group is higher than the control group ,but lighter and endurable .There is no significance in the difference of two groups＇sideeffect（P〉0.05）.Conclusion：The efficacy and safety of Citalopram combined with Aripiprazole in fhe treatment of refractory depression is better .