吗替麦考酚酯与环磷酰胺联合激素治疗V型狼疮性肾炎临床疗效观察 |
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引用本文: | 陈喜苹,王运贤.吗替麦考酚酯与环磷酰胺联合激素治疗V型狼疮性肾炎临床疗效观察[J].伤残医学杂志,2014(16):24-26. |
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作者姓名: | 陈喜苹 王运贤 |
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作者单位: | 南阳医学高等专科学校,河南南阳473061 |
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摘 要: | 目的:比较吗替麦考酚酯(MMF)与环磷酰胺(CTX)联合激素治疗V型狼疮性肾炎(LN)的临床疗效。方法:经肾活检诊断为V型活动期LN患者30例,通过随机数字表法分为2组,分别口服MMF和CTX静脉冲击治疗,同时均联合标准剂量的泼尼松治疗。比较分析2组的临床疗效以及经诱导治疗后发生的不良反应。结果:MMF组临床疗效的总有效率明显高于CTX组,差异有显著性统计学意义(P〈0.01);且MMF组不良反应的发生率低于CTX组。结论:MMF治疗V型病变的LN疗效明显优于CTX治疗,不良反应小。
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关 键 词: | 狼疮性肾炎 环磷酰胺 吗替麦考酚酯 治疗 |
Comparative study on therapeutic effect between mycophenolate mofetil and cyclophosphamide in treatment of pure class V lupus nephritis |
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Institution: | CHEN Xi - ping WANG Yun - xian The Nayang Medical College 473061 |
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Abstract: | Objective:To compare the clinical effect and safety between mycophenolate mofetil (MMF)and cyelophosphamide (CTX) in the treatment of pure class V lupus nephritis. Methods:30 female patients diagnosed class V LN, were randomly devided into Group MMF and Group CTX, respectively treated with MMF and CTX. Both groups were treated with standard dose prednisone. A comparative analysis of the clinical effects of two groups and compared with the occurring rate of adverse reactions. Results: MMF group's Syndromes assessment of the total efficiency than the CTX group, The difference was significant ( P 〈 0.01 ) ; And the incidence of adverse reactions was lower than the CTX group. Conclusion: MMF was more effective than CTX as the inducing treatment in patientswith class V LN and could have adverse effects. |
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Keywords: | Systemic lupus erythematosus Cyclophosphamide Mycophenolate mofetil Therapy |
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