GST基因多态性与儿童急性淋巴细胞白血病关联Meta分析

目的：探讨2个常见谷胱甘肽硫转移酶（glutathioneS-transferase，GST）GSTM1和GSTT1基因多态性与儿童急性淋巴细胞白血病（acutelymphoblasticleukemia，ALL）易感性的关系。方法：检索PubMed、EMBase、CBM、CNKI、VIP和万方数据平台从建库到2013-10-02的文献，提取相关数据。应用Stata11．0，选用合适的模型计算合并OR及95％CI，并进行发表偏倚检验。结果：共纳入17篇文献，21项研究。其中关于GSTM1与儿童ALL的研究21项，包含病例组2365例，对照组3885例。关于GSTT1与儿童ALL的研究20项，其中病例组2263例，对照组3744例。GSTM1纯合缺失基因型及GSTT1纯合缺失基因型合并0R分别为1．13（95％CI：1．03～1．23）和1．07（95％CI：0．94～1．22）。亚组分析发现，在亚洲人群及黑种人中GSTM1纯合缺失基因型增加儿童ALL的发病风险，OR分别为1．25（95％CI：1．07～1．45）和1．43（95％CI：1．03～1．23）；在白种人中GsTMl纯合缺失与儿童ALL．无明显相关性（OR=1．05；95％CI：0．94～1．18）；在亚洲人群中GSTTl纯合缺失增加儿童ALL的发病风险（OR=1．32；95％CI：1．08～1．60）；在白种人及黑种人中GSTTl纯合缺失与儿童ALL无明显相关（OR=0．92，95％CI：0．77～1．10；OR=0．95，95％CI：0．55～1．63）。结论：GSTM1纯合缺失基因型增加儿童ALL的发病风险，GSTT1纯合缺失基因型可增加亚洲儿童ALL的发病风险。GSTM1与GSTT1基因多态性与儿童ALL的易感性关联受人种影响。

Association of GST gene polymorphisms with the risk of childhood acute lymphoblastic Leukemia.a meta-analysis

OBJECTIVE：To assess the association of GSTT1 and GSTM1 polymorphisms with the risk of childhood acute lymphoblastic leukemia （ALL）. METHODS： A comprehensive search was conducted in Pubmed, EMBase, CBM, CNKI,VIP and Wan Fang database from inception to October 2,2013. Pooled ORs and their 95 % CIs were calculated by either fixed or random effect pooled measure, which was selected on the basis of heterogeneity test among studies. Publication bias was estimated using Beggs test. RESULTS： Seventeen publications were included. Twenty one studies on the GSTMl-childhood ALL association recruited 2 365 cases and 3 885 controls,while 20 studies on GSTT1 polymorphism recruited 2 263 cases and 3 744 controls. The pooled OR of childhood ALL risks associated with GSTM1 null genotype and GSTT1 null genotype were 1.13 （95%CI：1. 03-1. 23） and 1.07（95%CI：0.94-1.22） ,respectively. There was no hetero geneity among the studies. In subgroup analysis, significant association was found between GSTM1 polymorphism and childhood ALL in Asians and Blacks,the OR were 1. 25 （95% CI： 1. 07 - 1. 45） and 1. 43 （955CI： 1. 03 - 1. 23）. No significantassociation was found in whites and the OR was 1.05 （95 % CI： 0.94-1. 18）. Significant association was also tound be tween GSTT1 polymorphism and childhood ALL in Asians, the OR was 1.32 （95 % CI：1.08-1.60）. No significant asso ciation was found in whites and blacks,the OR were 0. 92（95%CI：0. 77-1.10） and 0.95 （95%CI：0. 55-1. 63） ,respectively. CONCLUSlONS..This meta-analysis suggests that the GSTM1 polymorphism was associated with an increased risk of childhood acute lymphoblastic Leukemia,while the GSTT1 polymorphism is associated with an increased risk of childhood acute lymphoblastic Leukemia for only the Asians. The above-mentioned two associations appear to vary by the ethnicity.