中国人群COMT Val158Met基因多态性与乳腺癌易感性Meta分析

目的：系统评价中国人群儿荼酚氧位甲基转移酶（catechol-O-methyltransferase，COMT）Vall58Met基因多态性与乳腺癌易感性的关系。方法：在PubMed、MEDLINE、webofScience、Embase、中国期刊全文数据库（CJFD）及万方数据库中检索1999-10-01-2012-01-01发表的所有有关中国人群COMTVall58Met基因多态性与乳腺癌易感性关系的相关文献，并按STREGA原则对文献进行筛选、评价。纳入文献均为病例对照研究，对照群体基因型分布均符合H-W遗传平衡定律。应用Stata 12．0软件进行Meta分析，计算合并0R值及95％CI，并进行敏感性分析和发表偏倚的估计。结果：按照入选标准，有11项病例对照研究纳入，包括乳腺癌患者3184例，健康对照4065例。Meta分析结果显示，与基因型Val／Val（GG）、Val／Met（GA）比较，基因型Met／Met（AA）均增加中国人群罹患乳腺癌的风险[OR=1．55，95％CI：1.03～2．33，P=0．035；OR-1．63，95％CI：1．10～2．42，P=0．015]；在隐性效应模型（Met／Met／vs Val／Val＋Val／Met）中，基因型Met／Met（AA）增加中国人群罹患乳腺癌的风险，0R-1．59，95％CI：1．07～2．36，P=0．021。与等位基因Val（G）比较，等位基因Met（A）不增加中国人群罹患乳腺癌的风险，OR=1．12，95％CI：0．96～1．32，P=0．157。结论：COMTVall58Met基因多态性与中国人群乳腺癌易感性相关，基因型Met／Met（AA）增加中国人群罹患乳腺癌的风险。

Association between COMT Val158Met polymorphism and breast cancer susceptibility in Chinese population.A Meta analysis

OBJECTIVE： To explore whether the Val158Met polymorphism in catechol-O-methyl transferase （COMT） gene contributes to the susceptibility to breast cancer risk in Chinese population. METHODS： All studies related to COMT Va1158Met polymorphism and breast cancer risk in Chinese population were searched in PubMed, MEDLINE, Web of Science,Embase,Web of Science, CJFD and WANFANG databases. The studies were selected and evaluated ac- cording to STREGA principle. The case-control studies involving related subjects and genotype frequencies in control group consistent with Hardy-Weinberg equilibrium were included. The pooled ORs with 95% CIs were calculated by Stata 12.0 software. Publication bias and sensitivity were also evaluated at the same time. RESULTS： Eleven case-control studies were included based on the selection criteria,involving 3184 patients with breast cancer and 4 065 controls. The pooled results indicated that, compared to Val/Val and Val/Met, COMT 158Met/Met genotype increased the susceptibility to breast cancer in Chinese population [（OR=I. 55,95%CI：1.03--2.33,P=0. 035） ,（OR- 1.63,95%CI：1.10--2.42,P= 0. 015）-]. In recessive model,COMT 158Met/Met genotype also increased the susceptibility to breast cancer in Chinese population （OR= 1.59,95 %CI： 1. 07--2. 36, P=0. 021）. The publication bias was not significant. Met（A） genotype didn＇t increase the risk of breast cancer （ OR = 1.12,95 % CI ： 0.96 --1.32, P = 0.157）. CONCLUSIONS ： COMT Vall 58 Met polymorphism seems to be involved in breast cancer risk. COMT 158Met/Met genotype increased the susceptibility to breast cancer in Chinese population.