亚临床甲状腺机能减退患者血脂、血糖、血尿酸水平变化

目的探讨亚临床甲状腺机能减退症患者血脂、血糖、血尿酸水平的变化及意义。方法 50例亚临床甲状腺机能减退(SCH)患者根据促甲状腺激素(TSH)水平分为观察组A(TSH<10 mIU/L,25例)和观察组B(TSH≥10 mIU/L,25例)。60例对照组患者为健康体检者。测患者血清中游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血糖、尿酸(UA)水平。结果与对照组比较,观察组血清TSH、TC、TG、LDL-C、UA水平明显升高(P<0.05),FT3、FT4、HDL-C水平明显降低(P<0.05),血糖水平无显著差异(P>0.05);观察组B增加/降低的更加明显(P<0.05)。结论亚临床甲状腺机能减退在促进动脉硬化的过程中,血脂代谢紊乱和高尿酸血症是重要的危险因素,而与血糖无关。

Changes of blood lipids, blood sugar and serum uric acid in patients with subclinical hypothyroidism

Objective To investigate the changes and significance of blood lipids,blood sugar,serum uric acid in patients with subclinical hypothyroidism(SCH).Methods Fifty patients with SCH were divided into observation group A(TSH<10 mIU/L,n=25) and the observation group B(TSH≥10 mIU/L,n=25) in accordance with thyroid stimulating hormone levels.The control group included 60 healthy individuals.The levels of the three triiodothyronine(FT3),free four iodine thyroid original acid(FT4),thyroid stimulating hormone(TSH),cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),glucose,uric acid(UA) in serum were detected.Results Compared with the control group,the levels of serum TSH,the TC,TG,LDL-C,and UA were significantly increased in the observation group(P<0.05).FT3,FT4 and HDL-C level was significantly lowered(P<0.05).Blood glucose levels had no significant difference(P>0.05).The increases or decreases were more pronounced in the observation group B(P<0.05).Conclusion Subclinical hypothyroidism is an important risk factor in the process of promoting atherosclerosis,dyslipidemia,and hyperuricemia,which is not related to blood sugar.