| β-内酰胺类抗生素对吗啡耐受及依赖作用 |
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| 引用本文： | 王萌,董华进,宫泽辉. β-内酰胺类抗生素对吗啡耐受及依赖作用[J]. 药学学报, 2008, 43(11) |
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| 作者姓名： | 王萌 董华进 宫泽辉 |
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| 作者单位： | 北京药理毒理研究所,北京,100850 |
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| 摘 要： | 为了研究头孢曲松及其类似物是否具有对抗吗啡耐受及依赖作用和头孢曲松对抗吗啡耐受的量效关系,本文采用小鼠热板舔足模型及纳洛酮戒断模型对头孢曲松、头孢拉定和头孢替安等6种β-内酰胺类抗生素进行观察,并与生理盐水对照组比较。100 mg.mL-1头孢曲松和头孢噻肟在吗啡形成耐受模型后第10天可能最大镇痛百分率(PMAP)分别为74.95%和65.94%,与生理盐水组(22.99%)比较具有显著性。100和50 mg.kg-1头孢曲松对戒断实验小鼠30 m in内平均跳跃次数为3.8和3.6,与对照组(20.9)比较具有显著性。结果表明,100 mg.kg-1头孢曲松和头孢噻肟对吗啡诱导的耐受和躯体依赖具有显著的抑制作用。头孢曲松具有剂量依赖性的抗吗啡耐受作用。
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| 关 键 词： | β-内酰胺类素 吗啡 耐受 依赖 |
Effects of β-lactam antibiotics on development of tolerance and dependence to morphine |
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| WANG Meng,DONG Hua-jin,GONG Ze-hui. Effects of β-lactam antibiotics on development of tolerance and dependence to morphine[J]. Acta pharmaceutica Sinica, 2008, 43(11) |
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| Authors: | WANG Meng DONG Hua-jin GONG Ze-hui |
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| Abstract: | In order to identify ceftriaxone and its analogs whether has the function of anti-tolerance of morphine and study the dose-effect relation of ceftriaxone in mice,hot plate method to measure pain threshold of mouse and naloxone withdrawal models were carried out and compared with normal saline group.Ceftriaxone and cefotaxime had the effect of anti-tolerance and anti-dependence of morphine notably.And ceftriaxone has the effect of anti-tolerance of morphine in a dose dependent manner. |
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