Synergism of rheolytic thrombectomy and embolic distal protection using the percusurge guardwire for fresh thrombus removal: An in vitro study |
| |
Authors: | Fadi Matar Kathy Gloer Chantel Barrett Olivia Sires Shaival Thakore Jennifer Warner |
| |
Affiliation: | 1. The Cardioquest Research Laboratories, Tampa, Florida, USAfmatar@fciheart.com;3. The Cardioquest Research Laboratories, Tampa, Florida, USA |
| |
Abstract: | OBJECTIVES: To test the effectiveness of Rheolytic Thrombectomy (RT) and distal protection balloon wires when used synergistically in an in vitro model. BACKGROUND: Although effective, currently available technologies may not be individually ideal for fresh clots removal. METHODS: Fourteen, fresh blood samples were placed in 14 plastic tubes and left to clot for 6?h. A Percusurge Guardwire balloon was inflated distal to the clot and aspiration was performed using RT in seven tubes and manual aspiration (MA) with the Export catheter in seven tubes. The residual clot in each tube was dried and weighed. Both aspiration systems were advanced over the Guardwire. RESULTS: During RT, none of the protection balloons ruptured and no retrograde clot embolization were observed. MA was most effective when the Export catheter tip was not in direct contact with the clot. The residual clot mass post RT was significantly less than post MA (9.7±2.2 versus 59.2±45.9, P = 0.01). CONCLUSION: RT is compatible with Distal Protection Balloon Wires and results in more complete clot removal than manual aspiration with the export catheter. Although manual aspiration results in a large variation in extraction efficacy, it is most effective when direct catheter‐clot contact is kept to a minimum. |
| |
Keywords: | Angioplasty percutaneous coronary intervention thrombectomy distal embolic protection |
|
|