| 类器官研究进展及应用 |
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| 引用本文： | 董研博,王健,郑梦竹,刘良发,李山虎.类器官研究进展及应用[J].中国药理学与毒理学杂志,2019(2):152-160. |
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| 作者姓名： | 董研博 王健 郑梦竹 刘良发 李山虎 |
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| 作者单位： | 1.首都医科大学附属北京友谊医院耳鼻咽喉头颈外科;2.军事科学院军事医学研究院生物工程研究所细胞工程实验室 |
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| 基金项目： | 国家自然科学基金(81672640);国家自然科学基金(81772750);国家科技重大专项(2018ZX09101001-003);首都医科大学附属北京友谊医院科研启动基金(yydszx2015-02)~~ |
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| 摘 要： | 类器官是一种新型体外研究模型,由干细胞或肿瘤细胞在三维培养条件下自我组装而成。它能够高度模拟原位组织的生理结构和功能,经长期传代保持遗传信息的稳定,因此类器官在构建疾病模型、药物筛选及个体化医疗等方面具有广阔前景。目前,食道、胃、肠、肝、胰、前列腺和乳腺等结构的类器官和相应的肿瘤类器官均已面世,开拓了体外培养的新平台。本文将对类器官的类型及其在生物医学领域的应用做一综述。
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| 关 键 词： | 类器官 三维培养 干细胞 药物筛选 个体化治疗 |
Research progress in organoids and applications |
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| DONG Yan-bo,WANG Jian,ZHENG Meng-zhu,LIU Liang-fa,LI Shan-hu.Research progress in organoids and applications[J].Chinese Journal of Pharmacology and Toxicology,2019(2):152-160. |
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| Authors: | DONG Yan-bo WANG Jian ZHENG Meng-zhu LIU Liang-fa LI Shan-hu |
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| Institution: | (Department of Otolaryngology,Head and Neck Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Cell Engineering,Institute of Biotechnology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China) |
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| Abstract: | An organoid is a novel in vitro model, formed by self-organization of stem cells or tumor cells under three-dimension culture. It recapitulates many aspects of structural organization and functionality of its in vivo organ counterparts and maintains the stability of genetic materials under long-term culture, thus holding great promise for modeling disease, drug screening and personalized medicine.So far, normal and tumor organoids from structures such as esophagus, stomach, intestine, liver, pancreas and prostate and mammary gland have been established, providing a new culture platform in vitro. This article reviews the classification and biomedical applications of organoids. |
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| Keywords: | organoid three-dimensional culture stem cell drug screening personalized therapy |
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