| Abstract: | The effect of benzene on colony-forming activity of the bone marrow and spleen was studied in four groups of experiments. In benzene hypoplasia of hematopoiesis, fewer colony-forming units were found in the hematopoietic organs although there was no change in the distribution of their cell types. Incubation of normal bone marrow cells with benzene did not reduce the efficiency of colony formation. Injection of benzene into lethally irradiated mice after transplantation of a suspension of normal bone marrow cells into the animals caused a sharp decrease in colony production, with inhibition chiefly of the formation of granulocytic colonies. These observations suggest that during benzene poisoning the properties of the microenvironment of the hematopoietic stem cell are modified.Presented by Academician of the Academy of Medical Sciences of the USSR A. A. Minkh.Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 7, pp. 797–799, July, 1976. |
