慢性束缚应激对健康大鼠血糖及血脂的影响

目的 观察慢性束缚应激模型大鼠血清甘油三酯、总胆固醇、低密度脂蛋白-胆固醇及血糖的变化规律.方法 健康雄性Wistar大鼠120只,随机分为束缚应激组及对照组,各60只,两组分别于1周、2周、4周、6周、8周时检测血清甘油三酯、总胆固醇、低密度脂蛋白-胆固醇、葡萄糖水平.结果 束缚应激组1周时,大鼠血清甘油三酯、总胆固醇、低密度脂蛋白.胆固醇、血糖水平与对照组相比均显著升高(P<0.05).束缚应激组大鼠除血糖与对照组相比表现为持续升高趋势外,甘油三酯、总胆固醇、低密度脂蛋白一胆固醇水平在慢性束缚应激第4周后均出现下降趋势,甚至低于对照组(P>0.05).结论 慢性束缚应激所引起的血清脂质水平改变呈各自不同的变化趋势,不同于急性应激.

Effects of chronic restraint stress on serum glucose and lipid in healthy rats

Objective To investigate the change of the content of triglyceride,total eholesterol,low-density lipoprotein-cholesterol and glucose in serum of the chronic restraint stress model ruts.Methods 120 healthy male Wistar rats were randomly devided into restraint stress group and control group,each group has 60 rats.The content of triglyceride, total cholesterol, low-density lipoprotoin-cholesterol and glucose in serum in two groups were detected after 1 week, 2 weeks,4 weeks,6 weeks and 8 weeks, respectively.Results Compared with the control group, serum triglyeeride, total cholesterol, low-density lipoprotein-cholesterol and glucose of the model rats were significantly increased after 1 week (P < 0.05).Compared with control group, serum glucose levels in the restraint stress mrs were gradually inerensed, while serum triglyceride, total cho-lesterol and low-density-cholesterol lipoprotein levels were decreased after 4 weeks, or even lower than the control group(P < 0.05).Conclusion Chronic restraint stress may cause the metabolic disorder of lipid, and is different from the effects of short-term stress.