A low prevalence of H pylori and endoscopic findings in HTV-positive Chinese patients with gastrointestinal symptoms |
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Authors: | Fu-Jing Lv Xiao-Lan Luo Xin Meng Rui Jin Hui-Guo Ding Shu-Tian Zhang |
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Institution: | 1. Department of Digestive Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China 2. Pathology Department, Beijing You'an Hospital,Capital Medical University, Beijing 100069, China 3. Department of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,China |
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Abstract: | AIM: To compare the prevalence of H pylori infection,peptic ulcer, cytomegalovirus (CMV) infection and Candida esophagitis in human immunodeficiency virus (HIV)-positive and HIV-negative patients, and evaluate the impact of CD4 lymphocyte on H pylori and opportunistic infections.METHODS: A total of 151 patients (122 HIV-positive and 29 HIV-negative) with gastrointestinal symptoms were examined by upper endoscopy and biopsy. Samples were assessed to determine the prevalence of H pylori infection,CMV, candida esophagitis and histologic chronic gastritis.RESULTS: The prevalence of H pylori was less common in HIV-positive patients (22.1%) than in HIV-negative controls (44.8%; P < 0.05), and the prevalence of H pylori displayed a direct correlation with CD4 count stratification in HIV-positive patients. In comparison with HIV-negative group, HIV-positive patients had a lower incidence of peptic ulcer (20.7% vs 4.1%; P < 0.01), but a higher prevalence of chronic atrophy gastritis (6.9% vs 24.6%; P < 0.05), Candida esophagitis and CMV infection. Unlike HIV-negative group, H pylori infection had a close relationship to chronic active gastritis (P<0.05). In HIV-positive patients, chronic active gastritis was not significantly different between those with H pylori infection and those without.CONCLUSION: The lower prevalence of H pylori infection and peptic ulcer in HTV-positive patients with gastrointestinal symptoms suggests a different mechanism of peptic ulcerogenesis and a different role of H pylori infection in chronic active gastritis and peptic ulcer.The pathogen of chronic active gastritis in HIV-positive patients may be different from the general population that is closely related to H pylori infection. |
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Keywords: | Human immunodeficiency virus Endoscopy Cytomegalovirus Candida esophagitis H pylori Peptic ulcer Chronic gastritis |
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