| 人参皂苷Rg1通过miR-138-5p/SIRT1轴诱导骨髓间充质干细胞向髓核样细胞增殖分化 |
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| 引用本文： | 岳宗进,刘汝银,于露,王新立,冯仲锴,李云朋.人参皂苷Rg1通过miR-138-5p/SIRT1轴诱导骨髓间充质干细胞向髓核样细胞增殖分化[J].中国现代应用药学,2022,39(1):27-35. |
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| 作者姓名： | 岳宗进 刘汝银 于露 王新立 冯仲锴 李云朋 |
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| 作者单位： | 河南省中医院脊柱科，郑州 450000 |
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| 基金项目： | 河南省中医药科学研究专项课题(2019ZYBJ18) |
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| 摘 要： | 目的 探讨人参皂苷Rg1诱导大鼠骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)向髓核样细胞(nucleus pulposus cells,NPCs)分化的机制.方法 从成年SD大鼠中分离培养BMSCs.通过CCK-8法检测不同浓度人参皂苷Rg1(0,2.5,5,10...
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| 关 键 词： | 骨髓间充质干细胞 髓核样细胞 miR-138-5p SIRT1 |
| 收稿时间： | 2021/4/2 0:00:00 |
Ginsenoside Rg1 Induces the Proliferation and Differentiation of Bone Marrow Mesenchymal Stem Cells into Nucleus Pulposusk-like Cells Through the miR-138-5p/SIRT1 Axis |
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| YUE Zongjin,LIU Ruyin,YU Lu,WANG Xinli,FENG Zhongkai,LI Yunpeng.Ginsenoside Rg1 Induces the Proliferation and Differentiation of Bone Marrow Mesenchymal Stem Cells into Nucleus Pulposusk-like Cells Through the miR-138-5p/SIRT1 Axis[J].The Chinese Journal of Modern Applied Pharmacy,2022,39(1):27-35. |
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| Authors: | YUE Zongjin LIU Ruyin YU Lu WANG Xinli FENG Zhongkai LI Yunpeng |
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| Institution: | Department of Spine, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450000, China |
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| Abstract: | |
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| Keywords: | bone marrow mesenchymal stem cells nucleus pulposus cells miR-138-5p SIRT1 |
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