熵权法结合灰色关联度法评价白芷饮片质量

目的 将熵权法与灰色关联度结合构建模型,对白芷饮片进行多指标综合质量评价研究.方法 测定来源于36个厂家的49批白芷饮片样品中浸出物、欧前胡素、异欧前胡素及欧前胡素与异欧前胡素的总和4个主要指标的含量,采用灰色关联度法,以熵权法所得权重作为分辨系数,构建白芷饮片质量评价模型.结果 49批白芷饮片的浸出物权重最大,提示含...

Quality Evaluation of Angelicae Dahuricae Radix Decoction Pieces by Entropy Weight and Gray Relative Analysis Method

OBJECTIVE To evaluate the quality of Angelicae Dahuricae Radix(ADR) decoction pieces by the entropy weight method and grey relative analysis(GRA) method.METHODS The content of extracts, imperatorin, isoimperatorin, and the sum of the imperatorin and isoimperatorin in 49 batches of ADR decoction pieces from 36 pharmaceutical manufacturers were determined. GRA, the weight of the entropy weight method was used as the resolution coefficient to construct the quality research model of the decoction pieces.RESULTS The content of extracts in 49 batches of ADR decoction pieces were the largest, which suggested that the content might need to increase more indicative ingredients. The relative correlation degree of each evaluation unit sequence was 0.190 4-0.809 8, which indicated that the quality of ADR decoction pieces from different producing areas and manufacturers were different. Most of the manufacturers were in Hebei Province, the relative correlation degree measured was large, the quality ranking was in the front, the sulfur dioxide residue was more than 5 mg·kg^-1, the relative correlation degree measured was small, the quality ranking was in the back, indicating that the current standard needed to be improved, standardized processing management was conducive to the quality control of ADR decoction pieces. The top five samples were S46, S31, S39, S32, S36 based on these two methods.CONCLUSION The comprehensive quality evaluation of ADR decoction pieces can be effectively evaluated by GRA and entropy weight method. Entropy weight method improves the reliability of GRA method as well as the scientificity of quality evaluation of ADR decoction pieces.