| Abstract: | Transplantation of fetal tissue in clinical practice in Russia has a solid experimental basis. “Tissue-tissue” relationships that are phylo- and ontogenetically fixed as characteristic of all systems of organs have been described in studies of Zavarzinet al. The method of tissue culture in the organism that was developed by Lazarenko in 1934 makes it possible to study the patterns of growth and transformation of tissues and organs in the living organism. This method has been used in studies of epithelial tissues of ecto-, endo-, and mesodermal origin. Five stages of the transplantation process have been identified: tissue depression, activation, tissue growth and differentiation, the period of functional activity, and atrophy. All tissues, except for endocrine tissue, which can live for a long time without atrophy, go through these stages, but in each tissue this process is genetically determined. This paper is focused on the close “tissue-tissue” relationships and presents characteristics of all epithelial tissues. Special attention is paid to the anterior portion of the gastrointestinal system and to the endocrine glands originating from it: adenohypophysis, thyroid gland, and thymus. The contribution of a normally functioning endocrine system to the successful transplantation of ovarian and mammary tissue is also discussed. After transplantation, epithelial tissues are transformed and assimilated in the recipient's organism. This may provide a basis for a novel approach to the problem of the immunological responsiveness of the organism. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N o 4, pp. 341–349, April, 1994 |
