三维适形放疗配合全脑照射治疗脑转移瘤的疗效观察 |
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作者单位: | Department of Radiotherapy, The Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China
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摘 要: |
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关 键 词: | 三维适形放疗 全脑放疗 脑转移瘤 三维适形放射治疗 平均存活时间 分割剂量 神经症状 放疗治疗 |
The effects of three-dimensional conformal radiotherapy combined with whole brain irradiation on brain metastases |
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Authors: | Jin Hu Yeqing Zhou Mi Liu |
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Institution: | Department of Radiotherapy, The Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China |
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Abstract: | Objective: To observe the recently therapeutic effects and toxicity of three-dimensional conformal radiotherapy combined with whole brain irradiation for patients with brain metastasis. Methods: 33 cases were treated by whole brain irradiation at first, the dose of which was 36-40 Gy (18-20 f). Then three-dimensional conformal radiotherapy was added to the focus with a total dose of 20-25 Gy, whose fractionated dose was 2-5 Gy/time, 5 times/week or 3 times/week. Results: Within 1 month after radiotherapy, according to imaging of the brain, the CR of all patients was 45.5%, PR 36.4%, NC 15.1%, and PD 3%. For the 32 cases with neural symptoms before radiation, the CR of the symptoms was 40.6% and PR 59.4%. All patients gained different increases in KPS grade. By the end of the follow-up period, there were 22 deaths with the mean survival time up to 9.3 months. Conclusion: Three-dimensional conformal radiotherapy combined with whole brain irradiation can not only effectively control brain metastases and improve life quality, but also tends to prolong survival time. |
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Keywords: | brain metastasis three-dimensional conformal radiotherapy whole brain irradiation effect |
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