NIDDM患者血清过氧化脂质及红细胞超氧化物歧化酶活性变化及其意义

为探讨糖尿病患者血清过氧化脂质（ＬＰＯ）和红细胞超氧化物歧化酶（ＳＯＤ）活性与血糖、视网膜病变的关系，对５３例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者检测了血清ＬＰＯ和红细胞ＳＯＤ活性。结果表明：ＮＩＤＤＭ患者血清ＬＰＯ水平高于正常对照组，且与糖化血红蛋白（ＨｂＡＩＣ）呈正相关，有视网膜病变者血清ＬＰＯ升高更明显，红细胞ＳＯＤ活性则低于正常对照组，并与ＨｂＡＩＣ呈负相关，有视网膜病变者降低更明显。提

MEASUREMENT AND CLINICAL SIGNIFICANCE OF ERYTHROCYTE SUPEROXIDE DISMUTASE AND PLASMA LIPID PEROXIDE IN PATIENTS WITH NIDDM

The activity of erythrocyte superoxide dismutase(SOD) and the level of plasma lipid peroxide (LPO) in 53 patients with non insulin diabeta mellitus(NIDDM) were determined.The results showed that the levels of LPO in NIDDM patients were higher than those of the normal controls,and were correlated with glycosylated hemoglobin (HbAIC).In the patients with retinopathy the LPO levels were significantly higher,while the activity of erythrocyte SOD was lower than those of the normal controls,and were inveresly correlated with HbAIC.In the patients with retinopathy the levels were significantly lower.These results shows that an increase in the plasma glucose may increase the reaction of lipid peroxide and free radicals and may lower the activity of superoxide dismutase in patients with NIDDM.These changes may be one of the primary factors that causes the early onset and high occurence of retinopathy in diabetes mellitus.