新生儿凝血功能的检测及临床意义

目的探讨新生儿凝血功能变化及其临床意义。方法测定50例正常新生儿和324例合并肠闭锁等先天性畸形新生儿的血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTr）、凝血酶时间（TT）及纤维蛋白原（FIB）含量，并与50例随机选取的正常成人凝血四项对照比较。结果先天性疾病组新生儿中的PT、AFFF、TT、FIB与正常新生儿组比较差异无统计学意义（P〉0．05），先天性疾病组中的门、APTT较正常成人对照组显著增高，差异有统计学意义（P〈0．05）；而FIB较正常成人对照组显著减低，差异有统计学意义（P〈0．05）。新生儿凝血功能指标临床参考区间：PT：12．28～14．57S，APTT：30．31—47．05S，TT：13．80～20．94S，FIB：1．61—3．07g/L。结论新生儿的凝血功能处于低凝状态，建立新生儿常规凝血功能参考区间，对凝血功能进行检测，可早期干预及指导新生儿手术治疗。

Detection of neonatal coagulation function and its clinical significance

Objective To investigate the changes of neonatal coagulation function and its clinical significance. Methods Fifty normal newborns and 324 neonate with intestinal atresia or other congenital malformations were chosen, and newborns prothrombin time （PT）, active partial thromboplastin time （AFIT）, thrombin time （Tr） and fibrinogen （FIB） content were measured respectively, then the coagulation four indices were compared with 50 cases of randomly selected normal adult. Results The values of PT, APTT, TT and FIB had no statistical differences between neonatal congenital diseases group and normal newborn group （ P 〉 0. 05 ）. The levels of PT and APTT in congenital disease group were significandy higher than those in normal adult control group （ P 〈 0.05 ） ; But FIB level was significantly lower than that in normal aduh control group（ P 〈 0.05 ）. The clinical reference ranges of neonatal blood coagulation function indexes were： PT： 12.28-14.57 s, APTT： 30. 31-47.05 s, and TT： 13.80-20.94 s, FIB ： 1.61-3.07 g/L. Conclusions The neonatal blood coagulation function is in a state of low level. Establish ment of the newborn normal coagulation function reference range to test the function of blood coagulation can early intervene and guide the neonatal surgical treatment.