| 三七中人参三醇甙对大鼠离体心脏缺血再灌注损伤及心律失常的保护作用 |
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| 引用本文： | 李学军,沈华杰,等.三七中人参三醇甙对大鼠离体心脏缺血再灌注损伤及心律失常的保护作用[J].中国药理学与毒理学杂志,1992,6(4):272-274. |
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| 作者姓名： | 李学军 沈华杰 |
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| 作者单位： | [1]北京医科大学药理教研室，北京100083 [2]山西大同卫校药 |
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| 基金项目： | 国家自然科学基金 № 3880639 |
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| 摘 要： | 三七中人参三醇甙(PTS)5,50μg·ml~(-1)灌流对离体大鼠Langendorff心脏缺血再灌注所致心律失常具有明显的保护作用,可降低室颤发生率,并可保护心肌组织中超氧化物歧化酶的降低,PTS 50μg·ml~(-1)还可抑制心肌丙二醛的产生,对缺血再灌注所致心肌乳酸脱氩酶和磷酸肌酸激酶的漏出亦有明显的抑制作用。
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| 关 键 词： | 三七 人参三醇甙 心肌缺血 再灌注 心律失常 超氧化物歧化酶 脂质过氧化 |
Protective effects of panaxatriol saponins isolated from Panax notoginseng (PTS) on ischemic-reperfused injury and arrhythmia in isolated rat hearts |
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| LIXue-Jun,SHEN Hua-Jie,XIN Hong-Bo,ZHANG Bao-Heng.Protective effects of panaxatriol saponins isolated from Panax notoginseng (PTS) on ischemic-reperfused injury and arrhythmia in isolated rat hearts[J].Chinese Journal of Pharmacology and Toxicology,1992,6(4):272-274. |
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| Authors: | LIXue-Jun SHEN Hua-Jie XIN Hong-Bo ZHANG Bao-Heng |
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| Institution: | LIXue-Jun,SHEN Hua-Jie,XIN Hong-Bo,ZHANG Bao-HengDepartment of Pharmacology,Beijing Medical University,Beijing 100083 |
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| Abstract: | The effects of PTS on myocardialischemic-reperfused injury and arrhythmias were studied in the Langendorffs perfused rat heart. The reperfusion-induced arrhythmias were prevented by PTS pretreatment at the concentration of 5 or 50μ·ml-1 respectively. The release of CPK and LDH from ischemic-reperfused hearts, as well as the production of MDA were inhibited by PTS at the concentration of 50 μg·?ml-1. It was also shown that there was a protective effect on SOD at PTS 5 and 50 μg ·ml-1 respectively. The results suggest that the PTS prevents the ischemic-reperfused myocardial injury and arrhythmia. The action is considered to be related to the inhibition of the free radical accumulation and lipid peroxidation. |
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| Keywords: | Panax notoginseng panaxatriol saponins ischemia reperfusion arrhythmia su peroxide dismutase lipid peroxidation |
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