| 五味子多糖微囊的制备及其体外释药特性考察 |
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| 引用本文： | 舒予,李小芳,刘玲,吴珊,文怡静,罗敏.五味子多糖微囊的制备及其体外释药特性考察[J].中国实验方剂学杂志,2014,20(5):27-31. |
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| 作者姓名： | 舒予 李小芳 刘玲 吴珊 文怡静 罗敏 |
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| 作者单位： | 成都中医药大学药学院, 成都 611137;中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 成都 611137;中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 成都 611137;中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 成都 611137;中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 成都 611137;中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 成都 611137 |
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| 基金项目： | 四川省教育厅重点项目（12ZA042） |
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| 摘 要： | 目的：优选五味子多糖微囊的喷雾干燥工艺并评价其质量和体外释药模式。方法：以壳聚糖为载体，采用喷雾干燥法制备五味子多糖微囊，以收率和载药量的综合评分为指标，通过正交试验考察药物与壳聚糖质量比、壳聚糖质量分数、进样速度、进风温度对制备工艺的影响，评价五味子微囊的质量并考察其体外释药特性。结果：最佳制备工艺为壳聚糖质量分数2.0%，五味子多糖与壳聚糖质量比1：3，进风温度160 ℃，进液速度5 mL·min-1，空气流速600 L·h-1；制备的微囊表面光滑圆整、无黏连，载药量22.71%，收率62.04%，包封率83.27%，平均粒径13.47 μm，1，8 h累积释药率分别为47.86%，84.19%，在0~8 h内拟合Higuchi动力学方程Q=29.365t1/2+11.033（r=0.955 7）。结论：采用喷雾干燥法制备的五味子多糖微囊包封率较高，具有一定缓释性能和突释效应。
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| 关 键 词： | 五味子多糖 壳聚糖 微囊 喷雾干燥法 体外释药试验 正交试验 |
| 收稿时间： | 2013/7/29 0:00:00 |
Preparation of Schisandrae Chinensis Fructus Polysaccharides Microcapsules and Investigation of Its in vitro Release Behavior |
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| SHU Yu,LI Xiao-fang,LIU Ling,WU Shan,WEN Yi-jing and LUO Min.Preparation of Schisandrae Chinensis Fructus Polysaccharides Microcapsules and Investigation of Its in vitro Release Behavior[J].China Journal of Experimental Traditional Medical Formulae,2014,20(5):27-31. |
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| Authors: | SHU Yu LI Xiao-fang LIU Ling WU Shan WEN Yi-jing and LUO Min |
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| Institution: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Standardization of Chinese Herbal Medicines, Ministry of Education, Ministry of State Key Laboratory Breeding Base of System Research and Development Utilization of TCM Resources, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Standardization of Chinese Herbal Medicines, Ministry of Education, Ministry of State Key Laboratory Breeding Base of System Research and Development Utilization of TCM Resources, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Standardization of Chinese Herbal Medicines, Ministry of Education, Ministry of State Key Laboratory Breeding Base of System Research and Development Utilization of TCM Resources, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Standardization of Chinese Herbal Medicines, Ministry of Education, Ministry of State Key Laboratory Breeding Base of System Research and Development Utilization of TCM Resources, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Standardization of Chinese Herbal Medicines, Ministry of Education, Ministry of State Key Laboratory Breeding Base of System Research and Development Utilization of TCM Resources, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China |
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| Abstract: | |
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| Keywords: | Schisandrae Chinensis Fructus polysaccharides chitosan microcapsules spray drying method in vitro release test orthogonal test |
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