脑缺血再灌注动物模型的血脑屏障损伤

背景:脑缺血再灌注后血脑屏障遭到破坏,引起脑水肿和脑出血,组织损伤程度加重。目的:总结分析脑缺血再灌注动物模型血脑屏障相关分子,在脑缺血再灌注后血脑屏障损伤中的作用。方法:以"Cerebral ischemia-reperfusion injury,blood brain barrier permeability,"为检索词,检索近十年PubMed数据库,文献检索语种限制为英文。以"脑缺血再灌注,血脑屏障"为检索词,检索5年内中国期刊全文数据库,文献检索语种限制为中文。纳入与脑缺血再灌注及血脑屏障损伤密切相关的研究;排除重复性研究。选取17篇总结分析。结果与结论:从炎症因子的浸润,基质金属蛋白酶的水解以及水通道蛋白的开放等方面总结脑缺血再灌注损伤后血脑屏障相关分子,提出多因素多环节调控血脑屏障功能。CIR后血脑屏障开放的3h时间窗为急性期抢救缺血半暗带关键点,基质金属蛋白酶的后期修复作用也可为新药研发提供依据。

Blood brain barrier injury in animal models after cerebral ischemia-reperfusion

BACKGROUND:Cerebral ischemia-reperfusion results in the breakdown on blood brain barrier,leading to cerebral hemorrhage,brain edema and the aggravated damage of brain tissue.OBJECTIVE:To summarize and analyze the effects of associated molecules on the blood-brain barrier damage in animal models after cerebral ischemia-reperfusion.METHODS:A computer-based online search of PubMed(2001-01/2011-12) and CNKI(2006-01/2011-12) was performed for related articles with the keywords of "cerebral ischemia-reperfusion injury,blood brain barrier permeability" in English and Chinese,respectively.Researches on cerebral ischemia-reperfusion injury and blood brain barrier permeability were included.Repetitive studies were excluded.A total of 17 articles were retained.RESULTS AND CONCLUSION:The molecules associated with blood brain barrier after cerebral ischemia-reperfusion injury were summarized from many aspects,such as inflammatory infiltration,matrix metalloproteinases hydrolysis and aquaporin opening.The blood-brain barrier function is regulated by many factors and many links.The 3-hour time window of the blood brain barrier opening after cerebral ischemia-reperfusion injury is crucial for the emergency treatment of ischemic penumbra.The later repairing effect of matrix metalloproteinase may provide basis for the drug innovation.