肾透明细胞癌组织中B7-H3的表达及意义 |
| |
引用本文: | 徐一鹏,朱绍兴,李永生,王敏.肾透明细胞癌组织中B7-H3的表达及意义[J].现代泌尿生殖肿瘤杂志,2012,4(2):97-100. |
| |
作者姓名: | 徐一鹏 朱绍兴 李永生 王敏 |
| |
作者单位: | 1. 福建医科大学协和临床医学院泌尿外科,福州,350001 2. 上海市第六人民医院泌尿外科 3. 福建医科大学附属协和医院泌尿外科 4. 泰山医学院临床医学系 |
| |
摘 要: | 目的 评价B7-H3在肾透明细胞癌组织中的表达及其与预后的关系.方法 采用免疫组化方法 检测154例肾透明细胞癌患者肿瘤标本中B7-H3的表达,分析其与患者临床病理因素以及术后生存时间之间的关系.结果 154例患者中,B7-H3阳性28例(18.18%),其中无瘤生存6例,复发7例,死亡15例,至最后随访日期,总生存期(OS)为(19.71±20.32)个月;B7-H3阴性126例(81.82%),其中无瘤生存119例,复发3例,死亡4例,OS为(33.47±18.32)个月,两者比较差异有统计学意义(P<0.05).单因素分析表明,B7-H3阳性表达患者在肿瘤大小、原发肿瘤分期、区域淋巴结转移、远处转移、临床分期等方面较阴性表达患者有明显差异,B7-H3阳性表达患者术后生存时间较阴性表达患者明显缩短.结论 B7-H3的表达可能与肾透明细胞癌的转移和进展有关,可以作为肾透明细胞癌的一个独立预后因素.
|
关 键 词: | 肾透明细胞癌 B7-H3 |
The expression and significance of B7-H3 in renal clear cell carcinoma |
| |
Authors: | XU Yi-peng ZHU Shao-xing LI Yong-sheng WANG Min |
| |
Institution: | .*Department of Urology,Union Clinical College of Fujian Medical University,Fuzhou 350001,China |
| |
Abstract: | Objective To evaluate the B7-H3 expression in renal clear cell carcinoma tissues and its relationship with prognosis.Methods Nephrectomy specimens from 154 patients treated for ccRCC were evaluated for B7-H3 expression by immunohistochemical staining.Relationship of B7-H3 expression with clinical and pathologic features were evaluated.Results B7-H3 expression by tumor cells was noted in 28 cases(18.18%),in which tumor-free survival in 6 cases,recurrence in 7 cases,and death in 15 cases.To the last follow-up period,the overall survival(OS) was(19.71±20.32) months.While B7-H3 negative expression by tumor cells was noted in 126 cases(81.82%),in which tumor-free survival among 119 cases,recurrence in 3 cases,and death in 4 cases.The OS was(33.47±18.32) months.The difference was statistically significant(P<0.05).Univariate analysis showed that B7-H3 expression in patients with tumor size,primary tumor stage,regional lymph node metastasis,distant metastasis,clinical stage are different from the negative patients,the patients’ survival time which shows B7-H3 positive was significantly shorter than the negative patients.Conclusions B7-H3 expression may be associated with renal cell carcinoma’s metastasis and progression.It can be regarded as an independent prognostic factor of the renal clear cell carcinoma. |
| |
Keywords: | Renal clear cell carcinoma B7-H3 |
本文献已被 CNKI 万方数据 等数据库收录! |
|