脊髓神经干细胞Niche的研究进展

背景:脊髓损伤是临床上常见的骨科疾病,大量工作聚焦于神经干细胞治疗脊髓损伤的研究上,脊髓神经干细胞Niche对神经干细胞的作用成为了新的热点。目的:综述脊髓神经干细胞Niche的相关研究进展。方法:应用计算机检索PubMed 1980-01/2011-11期间的相关文章,检索词为"neural stem cells,niche/microenvironment,spinalcord",并限定文章语言种类为English。同时计算机检索中国期刊全文数据库2003-01/2011-11期间的相关文章,检索词为"神经干细胞,微环境,脊髓损伤",并限定文章语言种类为中文。此外还手工查阅相关专著数部。结果与结论:共检索到文献483篇,最终纳入31篇。脊髓神经干细胞Niche为脊髓神经干细胞生存、自我更新以及分化提供了相对稳定的微环境,脊髓损伤后脊髓神经干细胞Niche的变化对脊髓神经干细胞的命运有着重要的影响。了解脊髓神经干细胞Niche中的神经干细胞、细胞组成、分子调节以及脊髓损伤后这一Niche中部分细胞的变化等的研究进展为应用神经干细胞治疗脊髓损伤提供了理论基础。

Research progress in spinal cord neural stem cell Niche

BACKGROUND: Spinal cord injury is a common orthopedic disease. A lot of work has been done to focus on neural stem cells for treating spinal cord injury. The effect of spinal cord neural stem cell Niche on neural stem cells has become a gradually increasing research area. OBJECTIVE: To summarize the related research progress in spinal cord neural stem cell Niche. METHODS: A computer-based online search of Pubmed (1980-01/2011-11) and CNKI (2003-01/2011-11) was performed for articles in English and Chinese respectively with the key words "neural stem cells, niche/microenvironment, spinal cord". In addition, manual search was performed. RESULTS AND CONCLUSION: A total of 483 articles were obtained, and finally 31 articles were included. The Niche provides a relatively stable microenvironment for survival, self-renewal and differentiation of spinal cord neural stem cells. After spinal cord injury, the change of Niche plays an important impact on the fate of spinal cord neural stem cells. Understanding the research progress of spinal cord neural stem cell Niche would provide a theoretical basis for treatment of spinal cord injury using neural stem cells.