| 人参、西洋参及刺五加皂甙对离体工作心脏作用的对比研究 |
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| 引用本文： | 曹霞,高宇飞,李红,杨红,杨世杰,杜雪荣.人参、西洋参及刺五加皂甙对离体工作心脏作用的对比研究[J].吉林大学学报(医学版),2001,27(3):246-248. |
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| 作者姓名： | 曹霞 高宇飞 李红 杨红 杨世杰 杜雪荣 |
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| 作者单位： | 1. 吉林大学基础医学院药理教研室
2. 吉林大学中日联谊医院中医科 |
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| 摘 要： | 目的 :比较人参茎叶皂甙 ( Gin S)、西洋参茎叶皂甙 ( PQS)及刺五加叶皂甙 ( ASS)对大鼠离体工作心脏血流动力学的影响。方法 :采用大鼠离体工作心脏 ,以心率、血压、左室内压峰值、左室内压最大上升和下降速率、左室舒张末期压力为观察指标 ,比较 3种皂甙的作用。结果 :Gin S、PQS、ASS均可使血压、左室内压峰值、左室内压最大上升和下降速率下降 ,呈现明显的负性肌力作用 ,与维拉帕米的作用相似 ,但三者的作用强度不同。结论 :Gin S、PQS、ASS均具有负性肌力作用 ,其中 Gin S作用最强 ,PQS次之 ,ASS较弱
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| 关 键 词： | 人参茎叶皂甙 西洋参茎叶皂甙 刺五加叶皂甙 离体工作心脏 心肌收缩性能 |
| 文章编号： | 0253-3707(2001)03-0246-03 |
| 修稿时间： | 2000年6月6日 |
Comparative study of effects of Ginsenosides,Panaquilons and Eleutherosides on isolated working heart |
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| CAO Xia ,GAO Yu fei ,LI Hong ,YANG Hong ,YANG Shi jie ,DU Xue rong.Comparative study of effects of Ginsenosides,Panaquilons and Eleutherosides on isolated working heart[J].Journal of Jilin University: Med Ed,2001,27(3):246-248. |
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| Authors: | CAO Xia GAO Yu fei LI Hong YANG Hong YANG Shi jie DU Xue rong |
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| Institution: | CAO Xia 1,GAO Yu fei *,LI Hong 1,YANG Hong 1,YANG Shi jie 1,DU Xue rong 2 |
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| Abstract: | Objective:The experiment was used to observe hemodynamic effects of Ginsenosides (GinS), Panaquilons (PQS) and Eleutherosides(ASS) on isolated working rat heart. Methods:Isolated working heat of Wistar rats was observed, and six parameters including HR, AP, LVSP, ±dp/dt max and LVEDP were taken as indexes. Results:Three medicines marked negative inotropic action, made decline in AP, LVSP,±dp/dt max and rise in LVEDP as effects of verapamil. Conclusion:Study of comparison shows that GinS, PQS and ASS all reduced the myocardial contractility, but effect of GinS is most significant, the next is PQS, That of ASS is weaker. |
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| Keywords: | Ginsenosides Panaquilons Eleutherosides isolated working heart myocardial contractive function |
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