| 白细胞介素17在慢性丙型肝炎患者免疫损伤中的作用 |
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| 引用本文： | 黄建宏,凌文辉,林心,禤彩云,郑通明.白细胞介素17在慢性丙型肝炎患者免疫损伤中的作用[J].国际检验医学杂志,2013,34(21):2819-2820. |
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| 作者姓名： | 黄建宏 凌文辉 林心 禤彩云 郑通明 |
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| 作者单位： | 珠海市人民医院／暨南大学附属珠海医院检验科,广东珠海519000 |
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| 基金项目： | 广东省医学科研基金资助项目（A2012614）. |
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| 摘 要： | 目的 探讨白细胞介素17（IL-17）在慢性丙型肝炎患者免疫损伤中的作用.方法 选择22例慢性丙型肝炎患者作为HCV组,20例健康志愿者作为对照组.分别采用实时聚合酶链反应（RT-PCR）、酶联免疫吸附测定（ELISA）检测血清HCV-RNA及IL-17,其余检测指标包括血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBIL）、凝血酶原时间（PT）、肌酐.结果 HCV组患者血清IL-17水平明显高于对照组（P＜0.05）.HCV组患者血清ALT、AST及HCV-RNA与血清IL-17水平显著相关（P＜0.05）.结论 IL-17可能参与了慢性丙型肝炎的免疫学发病机制.
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| 关 键 词： | 肝炎病毒属 肝炎 丙型 白细胞介素17 肝功能试验 |
Effects of inerleukin-17 on immunologic injury of patients with chronic hepatitis C |
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| Institution: | Huang Jianhong , Ling Wenhui , Lin Xing , Xuan Caiyun , Zhen Tongming (Department of Clinical Laboratory, Zhuhai Peoplets Hospital/Zhuhai Hospital Affiliated to Jinan University, Zhuhai, Guangdong 519000, China) |
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| Abstract: | Objective To investigate the effects of interleukin-17 on immunologic injury of patients with chronic hepatitis C. Methods Twenty-two patients with chronic hepatitis C were selected to serve as HCV group and 20 healthy volunteers as control group. Real time polymerase chain reaction（RT-PCR） and enzyme-linked immunosorbent assay（ELISA） were utilized to detect serum HCV-RNA and IL-17, respectively. The rest detection indexes include alanine aminotransferase（ALT）, aspartate aminotransferase（AST） ,total bilirubin（TBIL）,prothrombin time（PT） and creatinine. Results Serum IL-17 level of patients in HCV group was significant higher than that in control group（P〈0.05）. Serum ALT,AST and HCV-RNA of patients in HCV group showed a marked correlation with serum IL-17 （P〈 0. 05）. Conclusion IL-17 may involved in immunological pathogenesis of chronic hepatitis C. |
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| Keywords: | hepacivirus hepatitis C interleukin-17 liver function tests |
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