老年前列腺癌患者内分泌治疗后下尿路症状与膀胱老化

目的分析老年前列腺癌患者内分泌治疗后的下尿路症状及其对患者生活质量(QOL)的影响。方法对30例高龄前列腺癌接受内分泌治疗后病情稳定患者的下尿路症状进行问卷调查,B超检测前列腺体积。根据国际前列腺症状(IPSS)评分(储尿期症状评分+排尿期症状评分),判断各项评分与QOL的关系。结果前列腺癌患者接受内分泌治疗后腺体明显萎缩,均有不同程度的下尿路症状,并以储尿期症状为主,IPSS评分、储尿期症状评分与QOL呈正相关。结论老年前列腺癌患者在内分泌治疗后,梗阻因素不再是下尿路症状的主要原因,膀胱老化所致的储尿期症状成为了影响患者QOL的重要因素。

Analysis of the lower urinary tract symptoms in senile prostate cancer patients during endocrine therapy

Objective To analyze the effect of lower urinary tract symptoms（LUTS） on the life qualityof aged prostate cancer patients after androgen ablation therapy.Methods 30 aged prostate cancer patients treated with androgen ablation were asked about their LUTS by using the international prostate symptom score（IPSS） questionnaire,which was composed of the storage and voiding symptom subscore,followed by correlation analysis with the quality of life（QOL） score.Ultrasound tests were performed to assay the mass of the prostate.Results Although androgen ablation therapy led to the atrophy ofprostate,patients suffered from LUTS to different extents.The symptoms of urine storage were more prominent.Both IPSS score and urine storage score were positively correlated with QOL.Conclusions In aged prostate cancer patients treated with androgen ablation therapy,obstruction does not play an important role in LUTS.The storage symptoms caused by the aging bladder are important factors affecting the QOL of the aged patients.