慢性阻塞性肺疾病合并不成比例肺动脉高压临床特征及病因分析

目的探讨慢性阻塞性肺疾病(COPD)合并"不成比例"肺动脉高压(PAH)的临床特征,并研究"不成比例"PAH的病因。方法回顾性分析2009年6月～2012年10月在解放军533医院呼吸内科住院的51例COPD合并"不成比例"PAH患者的临床资料。结果 51例患者中,以慢性血栓栓塞性PAH最多见,占49.0%(25例),其次是间质性肺疾病占25.5%(13例),而自身免疫性疾病也可导致"不成比例"PAH的发生,占11.8%(6例),其他疾病占13.7%(7例)。结论慢性血栓栓塞是COPD患者出现"不成比例"PAH最主要的原因。

Clinical characteristics and causes of chronic obstructive pulmonary disease with out of proportion pulmonary artery hypertension

Objective To explore the clinical characteristics of chronic obstructive pulmonary disease（COPD） with ＂out of proportion＂ pulmonary artery hypertension（PAH） and to investigate the causes associated with ＂out of proportion＂ PAH.Methods The clinic datum of 51 patients with COPD and ＂out of proportion＂PAH from June 2009 to October 2012 were reviewed.Results Chronic thromboembolism（CTE） was the most common cause in 51 patients with COPD and＂out of proportion＂PAH;its rate was 49.0%（25/51）.Secondly,the rate of interstitial lung disease was 25.5%（13/51）.The autoimmune diseases was a also an important cause,with a rate of 11.8%（6/51）.The rate of other diseases was 13.7%（7/51）.Conclusions CTE may be the most common cause of ＂out of proportion＂ PAH in patients with COPD.