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A mathematical description of nerve fiber bundle trajectories and their variability in the human retina |
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| Authors: | N.M. Jansonius J. Nevalainen B. Selig P.A. Sample J.B. Jonas P.J. Airaksinen L.A. Levin J. Paetzold |
| Affiliation: | a Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands b Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands c University Eye Hospital Oulu, Finland d Centre for Ophthalmology, University of Tübingen, Germany e Hamilton Glaucoma Center, University of California, San Diego, USA f Private Practice, Essen-Steele, Germany g University Eye Hospital Mannheim, Germany h University Eye Hospital Freiburg, Germany i Department of Medical Biometry, University of Tübingen, Germany j Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA k Department of Ophthalmology, University of Montreal, Canada |
| Abstract: | We developed a mathematical model wherein retinal nerve fiber trajectories can be described and the corresponding inter-subject variability analyzed. The model was based on traced nerve fiber bundle trajectories extracted from 55 fundus photographs of 55 human subjects. The model resembled the typical retinal nerve fiber layer course within 20° eccentricity. Depending on the location of the visual field test point, the standard deviation of the calculated corresponding angular location at the optic nerve head circumference ranged from less than 1° to 18°, with an average of 8.8°. |
| Keywords: | Glaucoma Neuro-ophthalmology Perimetry Optic nerve head |
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