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Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: A comparative study |
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| Authors: | Guillermo Parrilla-Reverter Marta Agudo Francisco Nadal-Nicolás Manuel Jiménez-López Paloma Sobrado-Calvo María P Villegas-Pérez |
| Institution: | a Laboratorio de Oftalmología Experimental, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain b Servicio Murciano de Salud, Hospital Universitario Virgen de la Arrixaca, 30120 Murcia, Spain |
| Abstract: | We examined qualitatively and quantitatively in adult rat retinas the temporal degeneration of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC). Retinal ganglion cell (RGC) axons were identified by their heavy neurofilament subunit phosphorylated isoform (pNFH) expression. Optic nerve injury induces a progressive axonal degeneration which after IONT proceeds mainly with abnormal pNFH-accumulations in RCG axons and after IONC in RGCs somas and dendrites. Importantly, this aberrant pNFH-expression pattern starts earlier and is more dramatic after IONT than after IONC, highlighting the importance that the type of injury has on the time-course of RGC degeneration. |
| Keywords: | IONC intra-orbital optic nerve crush IONT intra-orbital optic nerve transection RGCs retinal ganglion cells pNFH phosporylated isoform of the heavy neurofilament subunit |
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