Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor |
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| Authors: | Changquan Ling Min LI Jinxing Tan and Junhua Lu |
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| Institution: | (1) Changhai Hospital. The Second Military Medical University, 200433 Shanghai;(2) The Public Sanitary Department of the Second Military Medical Univeristy, china |
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| Abstract: | Objective: To probe the relationship of glucocorticoid receptor and some Chinese medicinal herbs.Methods: The model of Qi-Yang exhaustion and Qi-Yin exhaustion were made with hemorrhagic rats and heat-stressed rats respectively.
The effect of Shenfu decoction (SFD) and Shengmai powder (SMP) on plasma glucocorticoid (GC) and its receptor (GcR) in hepatic
cytosol of the models were measured respectively.Results: The activity of GcR decreased in both models, while their blood level of GC increased markedly. SFD and SMP showed no regulating
effect on blood GC, but displayed obvious up-regulation on GcR level in both models.Conclusion: SFD and SMP could up-regulate the activity of GcR in Qi-Yang and Qi-Ying exhaustion models.
This study was supported by National Natural Science Foundation (No. 30670882) |
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| Keywords: | Shenfu decoction Shengmai powder glucocorticoid receptor |
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