多指标正交试验优选罗布麻定时脉冲片提取工艺

目的:对罗布麻定时脉冲片进行提取工艺优选。方法:以金丝桃苷、总黄酮和浸膏得率为检测指标,采用多指标正交试验法进行提取工艺研究,得罗布麻定时脉冲片的最佳提取工艺。结果:罗布麻定时脉冲片最优提取工艺为:罗布麻叶加水提取2次,第1次加入10倍量水回流提取2.0 h,第2次加入8倍量水回流提取1.5 h。结论:多指标正交试验可用于罗布麻定时脉冲片提取工艺优化,为罗布麻定时脉冲片的制剂研究提供理论依据。

Optimization Investigation of Extraction Technology of Apocynum Delayed Pulse-release Tablet by Orthogonal Test with Multi-targets

Objective: To optimize the extraction technology of Apocynum delayed pulse-release tablet. Method: With the indicators of hyperin, flavonoids and extract yield, orthogonal test was carried out to achieve the best extraction technology of Apocynum delayed pulse-release tablet by the multiple guidelines grading method. Result: The best extraction technology was to extract for two times,the first time was to extract for 1.5 h with 10 fold water and the second time was to extract for 1.0 h with 8 fold water. Conclusion: The multiple guidelines grading method can be used to optimize the extraction technology for Apocynum delayed pulse-release tablet, and it provides a theoretical basis for its preparation.