清金降火汤加减联合阿奇霉素对痰湿闭阻型小儿支原体肺炎患者的临床疗效

目的探讨清金降火汤加减联合阿奇霉素对痰湿闭阻型小儿支原体肺炎患者的临床疗效。方法 210例患者随机分为清金降火汤加减组、阿奇霉素组、联合组,每组70例,疗程14 d。检测临床疗效、肺功能指标(PEF、VPTEF、TPTEF、PFV)、血清抗炎因子(IL-2、IL-4、IL-10、IL-13)、血清促炎因子(TNF-α、IFN-γ、IL-6、IL-8)、血清免疫功能指标(CD^3+、CD^4+、CD^8+、RBC-ICR)、不良反应发生率变化。结果联合组总有效率、VPTEF、TPTEF、PFV、IL-2、IL-13、CD3+、CD4+高于清金降火汤加减组、阿奇霉素组(P<0.05),PEF、IL-4、IL-10、TNF-α、IFN-γ、IL-6、IL-8、CD^8+、RBC-ICR降低(P<0.05),不良反应发生率低于阿奇霉素组(P<0.05)。结论清金降火汤加减联合阿奇霉素可有效改善痰湿闭阻型小儿支原体肺炎患者肺功能、血清炎性因子、免疫功能,安全性较高。

Clinical effects of Modified Qingjin Jianghuo Decoction combined with azithromycin on patients with pediatric mycoplasma pneumoniae pneumonia due to Phlegm-Dampness Accumulation

AIM To explore the clinical effects of Modified Qingjin Jianghuo Decoction combined with azithromycin on patients with pediatric mycoplasma pneumoniae pneumonia due to Phlegm-Dampness Accumulation.METHODS Two hundred and ten patients were randomly assigned into Modified Qingjin Jianghuo Decoction group(70 cases),azithromycin group(70 cases)and combination group(70 cases),all of which were given 14-day administration.The changes in clinical efficacy,pulmonary function indices(PEF,VPTEF,TPTEF,PFV),serum anti-inflammatory factors(IL-2,IL-4,IL-10,IL-13),serum pro-inflammatory factors(TNF-α,IFN-γ,IL-6,IL-8),serum immune function indices(CD^3+,CD^4+,CD^8+,RBC-ICR)and incidence of adverse reactions were detected.RESULTS The combination group demonstrated higher total effective rate,VPTEF,TPTEF,PFV,IL-2,IL-13,CD^3+,CD^4+than the Modified Qingjin Jianghuo Decoction group and azithromycin group(P<0.05),along with decreased PEF,IL-4,IL-10,TNF-α,IFN-γ,IL-6,IL-8,CD^8+,RBC-ICR(P<0.05),which also exhibited lower incidence of adverse reactions than the azithromycin group(P<0.05).CONCLUSION For the patients with pediatric mycoplasma pneumoniae pneumonia due to Phlegm-Dampness Accumulation,Modified Qingjin Jianghuo Decoction combined with azithromycin can effectively improve pulmonary functions,serum inflammatory factors and immune functions with high safety.