| 三七内生真菌Cladosporium sp.化学成分的研究 |
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| 引用本文： | 刘毅,叶颖晓,阮元,刘淼,麻兵继. 三七内生真菌Cladosporium sp.化学成分的研究[J]. 中成药, 2020, 0(8): 2067-2071 |
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| 作者姓名： | 刘毅 叶颖晓 阮元 刘淼 麻兵继 |
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| 作者单位： | 安庆医药高等专科学校药学系;河南农业大学农学院 |
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| 基金项目： | 安徽省高校自然科学研究重点项目(KJ2019A1235);安徽省高等学校省级质量工程项目(2018jxtd026);安徽省高校优秀青年骨干人才国内访问研修项目(gxgnfx2018094)。 |
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| 摘 要： | 目的研究三七Panax notoginseng Burk. F.H.Chen内生真菌Cladosporium sp.的化学成分。方法内生真菌固体发酵物甲醇-二氯甲烷提取物乙酸乙酯萃取部位采用硅胶、Sephadex LH-20、HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为3β-羟基-麦角甾-5, 7, 22-三烯(1)、3β-羟基-5α, 8α-过氧化麦角甾-6, 22-二烯(2)、亚油酸(3)、麦角甾-4, 6, 8 (14), 22-四烯-3-酮(4)、肉桂酸(5)、3, 10-二羟基-4, 8-二甲氧基-6-甲基苯甲香豆素(6)、p-香豆酸(7)、R-甲瓦龙酸内酯(8)、(1H-indol-3-yl)-oxoacetamide(9)、7, 8-dihydroxy-9,12 (Z,Z)-octadecadienoic acid (10)。结论化合物5～9均为首次从该内生真菌中分离得到。
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| 关 键 词： | 三七 内生真菌 Cladosporium sp. 化学成分 分离鉴定 |
Chemical constituents of endophytic fungus Cladosporium sp.from Panax notoginseng |
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| LIU Yi,YE Ying-xiao,RUAN Yuan,LIU Miao,MA Bing-ji. Chemical constituents of endophytic fungus Cladosporium sp.from Panax notoginseng[J]. Chinese Traditional Patent Medicine, 2020, 0(8): 2067-2071 |
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| Authors: | LIU Yi YE Ying-xiao RUAN Yuan LIU Miao MA Bing-ji |
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| Affiliation: | (Department of Pharmacy,Anqing Medical College,Anqing 246052,China;College of Agronomy,Henan Agricultural University,Zhengzhou 450000,China) |
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| Abstract: | AIM To study the chemical constituents of endophytic fungus Cladosporium sp.from Panax notoginseng Burk.F.H.Chen.METHODS The ethyl acetate fraction of methanol-dichloromethane extract of the endophytic fungus Cladosporium sp.from P.notoginseng was isolated and purified by silica,Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as ergosta-5,7,22-triene-3β-ol(1),3β-hydroxy-5α,8α-peroxide ergosta-6,22-diene(2),linoleic acid(3),ergosta-4,6,8(14),22-tetraen-3-one(4),cinnamic acid(5),3,10-dihydroxy-4,8-dimethoxy-6-methylbenzocoumarin(6),p-coumaric acid(7),R-mevalonolactone(8),(1H-indol-3-yl)-oxoacetamide(9),7,8-dihydroxy-9,12(Z,Z)-octadecadienoic acid(10).CONCLUSION Compounds 5-9 are isolated from this endophytic fungus for the first time. |
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| Keywords: | Panax notoginseng Burk.F.H.Chen endophytic fungi Cladosporium sp. chemical constituents isolation and identification |
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