首页 | 本学科首页   官方微博 | 高级检索  
检索        

加味茵陈蒿汤联合常规治疗对慢性持续期湿热型支气管哮喘患者的临床疗效
引用本文:张新恒,马蓉.加味茵陈蒿汤联合常规治疗对慢性持续期湿热型支气管哮喘患者的临床疗效[J].中成药,2020(3):640-644.
作者姓名:张新恒  马蓉
作者单位:乌鲁木齐幸福路社区卫生服务中心;新疆维吾尔自治区中医医院
基金项目:新疆维吾尔自治区自然科学基金(2014211C095)。
摘    要:目的探讨加味茵陈蒿汤联合常规治疗对慢性持续期湿热型支气管哮喘患者的临床疗效。方法 128例患者随机分为对照组和观察组,每组64例,对照组给予常规治疗(孟鲁司特钠、吸入型β2受体激动剂等),观察组在此基础上加用加味茵陈蒿汤,疗程4周。检测临床疗效、中医证候评分、儿童哮喘控制测试问卷(C-ACT)评分、呼气峰流量(PEF)、辅助性T细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg、白介素-17(IL-17)、转化生长因子-β1(TGF-β1)、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、Th17、Th17/Treg、IL-17降低(P<0.05),C-ACT评分、PEF、Treg、TGF-β1升高(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论加味茵陈蒿汤联合常规治疗可有效调控慢性持续期湿热型支气管哮喘患者外周血Th17/Treg细胞平衡,缓解临床症状,改善肺功能,耐受性较好。

关 键 词:加味茵陈蒿汤  常规治疗  支气管哮喘  湿热  慢性持续期

Clinical effects of Supplemented Yinchenhao Decoction combined with routine treatment on patients with bronchial asthma due to Damp-Heat Pattern at chronic persistent stage
ZHANG Xin-heng,MA Rong.Clinical effects of Supplemented Yinchenhao Decoction combined with routine treatment on patients with bronchial asthma due to Damp-Heat Pattern at chronic persistent stage[J].Chinese Traditional Patent Medicine,2020(3):640-644.
Authors:ZHANG Xin-heng  MA Rong
Institution:(Urumqi Happiness Road Community Health Service Center,Urumqi 830002,China;Xinjiang Uighur Autonomous Regional Hospital of Traditional Chinese Medicine,Urumqi 830000,China)
Abstract:AIM To explore the clinical effects of Supplemented Yinchenhao Decoction combined with routine treatment on patients with bronchial asthma due to Damp-Heat Pattern at chronic persistent stage.METHODS One hundred and twenty-eight patients were randomly assigned into control group(64 cases) for 4-week intervention of routine treatment(such as montelukast sodium, suction-type β2receptor agonist), and observation group(64 cases) for 4-week intervention of both Supplemented Yinchenhao Decoction and routine treatment. The changes in clinical efficacy, TCM syndrome score, child asthma control test questionnaire(C-ACT) score, peak expiratory flow(PEF), T helper 17(Th17), T regulatory(Treg), Th17/Treg, interleukin-17(IL-17), transforming growth factor-β1(TGF-β1), and occurrence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05). After the treatment, the two groups displayed decreased TCM syndrome score, Th17, Th17/Treg and IL-17(P<0.05), and increased C-ACT score, PEF, Treg and TGF-β1(P<0.05), especially for the observation group(P<0.05). No statistical significance existed in occurrence of adverse reactions between the two groups(P>0.05).CONCLUSION For the patients with bronchial asthma due to Damp-Heat Pattern at chronic persistent stage, Supplemented Yinchenhao Decoction combined with routine treatment can effectively regulate the balance of Th17/Treg cells in peripheral blood, relieve clinical symptoms and improve lung functions, with good tolerance.
Keywords:Supplemented Yinchenhao Decoction  routine treatment  bronchial asthma  Damp-Heat  chronic persistent stage
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号