肾炎舒片、还原型谷胱甘肽联合常规治疗对急性肾小球肾炎患者的临床疗效

目的探讨肾炎舒片、还原型谷胱甘肽联合常规治疗对急性肾小球肾炎患者的临床疗效。方法 136例患者随机分为对照组和观察组,每组68例,对照组给予常规治疗(控制钠盐和蛋白质摄入、头孢呋辛钠、利尿剂等),观察组在对照组基础上加用肾炎舒片、还原型谷胱甘肽。检测临床疗效、临床症状及体征恢复时间、肾功能指标(24 h尿蛋白、血清尿素氮及肌酐、尿红细胞排泄率)、白介素-10 (IL-10)、肿瘤坏死因子-α(TNF-α)、不良反应发生率、满意率变化。结果观察组总有效率、满意率高于对照组(P<0. 05),临床症状及体征恢复时间更短(P<0. 05)。治疗后,2组肾功能指标、IL-10、TNF-α改善(P<0. 05),以观察组更明显(P<0. 05);不良反应发生率较低,组间比较差异无统计学意义(P>0. 05)。结论肾炎舒片、还原型谷胱甘肽联合常规治疗可改善急性肾小球肾炎患者肾功能,提高临床疗效。

Clinical effects of Shenyanshu Tablets and reduced glutathione combined with routine treatment on patients with acute glomerulonephritis

AIM To explore the clinical effects of Shenyanshu Tablets and reduced glutathione combined with routine treatment on patients with acute glomerulonephritis. METHODS One hundred and thirty-six patients were randomly assigned into control group( 68 cases) for intervention of routine treatment( such as control of natrium salt and protein intake,cefuroxime sodium,diuretics),and observation group(68 cases) for Shenyanshu Tablets,reduced glutathione and routine treatment. The changes in clinical efficacy,recovery time of clinical symptoms and signs,renal function indices( 24 h urine protein,serum urea nitrogen and creatinine,excretion rate of urinary erythrocytes),interleukin-10( IL-10),tumor necrosis factor-α( TNF-α),incidence of adverse reactions and satisfaction rate were detected. RESULTS The observation group demonstrated higher total effective rate and satisfaction rate than the control group( P<0. 05),along with shorter recovery time of clinical symptoms and signs( P<0. 05). After the treatment,the two groups displayed improved renal function indices,IL-10 and TNF-α( P <0. 05),especially for the observation group( P<0. 05),both of which exhibited low incidence of adverse reactions without statistical significance( P>0. 05). CONCLUSION For the patients with acute glomerulonephritis,Shenyanshu Tablets and reduced glutathione combined with routine treatment can improve renal functions and elevate clinical efficacy.