| 多发性肌炎/皮肌炎治疗研究进展 |
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| 引用本文： | 吴炜,邓丹琪. 多发性肌炎/皮肌炎治疗研究进展[J]. 中国皮肤性病学杂志, 2020, 0(3): 338-342 |
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| 作者姓名： | 吴炜 邓丹琪 |
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| 作者单位： | 昆明医科大学第二附属医院皮肤性病科 |
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| 摘 要： | 多发性肌炎/皮肌炎(polymyositis,PM/dermatomyositis,DM)是以侵犯骨骼肌为主,可累及肌肉、肺、肾等多个脏器的自身免疫性疾病,其临床表现复杂,患者多因肺间质病变、肿瘤等并发症死亡,治疗以糖皮质激素为主,以及免疫抑制剂、生物制剂等,但不良反应大,对相关并发症的效果不理想。而干细胞移植治疗是作为当前治疗难治性PM/DM的一种手段。本文从PM/DM的治疗现状出发进行综述,以期为PM/DM临床治疗提供更多参考。
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| 关 键 词： | 多发性肌炎/皮肌炎 干细胞移植 治疗现状 |
The Development of Treatment for Polymyositis/Dermatomyositis |
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| WU Wei,DENG Danqi. The Development of Treatment for Polymyositis/Dermatomyositis[J]. The Chinese Journal of Dermatovenereology, 2020, 0(3): 338-342 |
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| Authors: | WU Wei DENG Danqi |
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| Affiliation: | (Department of Dermatology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China) |
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| Abstract: | Polymyositis(PM)/dermatomyositis(DM)is an autoimmune disease that mainly affects skeletal muscle,and it can cause damage to muscles,lungs and kidneys as well as other organs.Its clinical manifestations are complicated and patients could die due to complications such as pulmonary interstitial lesions and tumors;Glucocorticoids,immunosuppressants,and biological agents are the main management,but the adverse reactions are large,and the effect on related complications are not satisfactory.Stem cell transplantation therapy is relatively safe and effective as a means of treating refractory PM/DM.This article reviews the current status of treatment of PM/DM,in order to provide more reference for the clinical treatment of PM/DM. |
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| Keywords: | Polymyositis(PM)/dermatomyositis(DM) Stem cell transplantation Treatment status |
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