| 尿外泌体microRNAs在肾脏疾病中的研究进展 |
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| 引用本文： | 吕婕,李珉珉. 尿外泌体microRNAs在肾脏疾病中的研究进展[J]. 中国病理生理杂志, 2020, 0(2): 378-384 |
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| 作者姓名： | 吕婕 李珉珉 |
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| 作者单位： | 暨南大学附属第一医院临床医学检验中心 |
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| 基金项目： | 广东省新药筛选整点实验室开放基金资助项目(No.GDKLNDS-2018OF003) |
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| 摘 要： | <正>肾脏疾病的发病率和死亡率在全球范围内呈上升趋势[1]。早发现、早干预和早治疗对改善预后至关重要。但目前临床广泛应用的血清肌酐和血尿素氮等指标受到的影响因素多,且缺乏足够的灵敏性。研究表明只有当肾小球滤过率降低50%以上时,血清肌酐水平才有明显上升,不能在早期反映肾小球
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| 关 键 词： | 外泌体 尿 肾脏疾病 微小RNA |
Progress of urinary exosome microRNAs in kidney diseases |
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| Lü Jie,LI Min-min. Progress of urinary exosome microRNAs in kidney diseases[J]. Chinese Journal of Pathophysiology, 2020, 0(2): 378-384 |
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| Authors: | Lü Jie LI Min-min |
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| Affiliation: | (Center of Clinical Laboratory Medicine,The First Affiliated Hospital of Jinan University,Guangzhou 510630,China) |
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| Abstract: | Exosomes are extracellular vesicles that are actively released from all types of cells to various body fluids under the physiological and pathological conditions. It can be used as an intercellular signaling carrier by transferring specific components such as proteins, lipids and nucleic acids, which mediates the transmission of information between cells, thereby affecting the biological function of the recipient cells. Urinary exosomes are secreted by various cells in the urinary system and released into the urine. Recent studies have shown that changes of urinary exosome microRNAs can be used as biomarkers in kidney diseases for monitoring the changes of diseases and judging prognosis, and also have important value in the disease treatment. This article reviews the progress of urinary exosome microRNAs in kidney diseases. |
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| Keywords: | Exosome Urine Kidney diseases MicroRNAs |
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