| Cre-loxP系统条件性基因敲除小鼠在角质形成细胞研究中的应用进展 |
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| 引用本文： | 杨璐,杨永生,徐金华.Cre-loxP系统条件性基因敲除小鼠在角质形成细胞研究中的应用进展[J].中国皮肤性病学杂志,2020(3):319-323. |
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| 作者姓名： | 杨璐 杨永生 徐金华 |
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| 作者单位： | 复旦大学附属华山医院皮肤科 |
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| 基金项目： | 国家自然科学基金(81673060)。 |
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| 摘 要： | 在角质形成细胞(KC)的分化、发育,KC肿瘤的发生、发展以及KC的炎症和死亡过程中,仍有许多基因发挥的作用尚未明确。基于Cre-loxP系统的KC特异性基因敲除小鼠模型有助于理解皮肤疾病的发生机制,寻找具有针对性的治疗策略。本文主要对Cre-loxP系统条件性基因敲除小鼠的构建方法及其在KC相关研究中的应用进展进行阐述。
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| 关 键 词： | Cre-loxP系统 条件性基因敲除小鼠 角质形成细胞 |
Progress of Conditional Gene Knockout Mice Based on Cre-loxP System in the Study of Keratinocytes |
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| YANG Lu,YANG Yongsheng,XU Jinhua.Progress of Conditional Gene Knockout Mice Based on Cre-loxP System in the Study of Keratinocytes[J].The Chinese Journal of Dermatovenereology,2020(3):319-323. |
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| Authors: | YANG Lu YANG Yongsheng XU Jinhua |
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| Institution: | (Department of Dermatology,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China) |
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| Abstract: | In the process of development and differentiation of keratinocyte(KC),generation and progression of KC carcinoma,as well as the inflammation and death of KC,there still have been many genes whose functions were not yet clear.KC-specific gene knockout mice model based on Cre-loxP system could help to understand the pathogenesis of skin diseases and find new therapeutic targets.In this paper,the construction method of conditional gene knockout mice through Cre-loxP system and its application in KC related research were reviewed. |
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| Keywords: | Cre-loxP system Conditional knockout mice Keratinocytes |
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