| 葫芦素B固体分散体的制备 |
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| 引用本文： | 程佳慧,武倩,刘喜纲.葫芦素B固体分散体的制备[J].中成药,2020(3):570-573. |
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| 作者姓名： | 程佳慧 武倩 刘喜纲 |
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| 作者单位： | 承德医学院中药研究所 |
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| 基金项目： | 河北省高等学校科学技术研究项目(QN2018057);河北省高校重点学科建设项目(冀教高[2013]4)。 |
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| 摘 要： | 目的制备葫芦素B固体分散体。方法溶剂法制备固体分散体后,以溶出度为评价指标筛选药物-载体(PVP K30)比例。扫描电子显微镜(SEM)、傅里叶变换红外光谱(FTIR)、差示扫描量热(DSC)、X射线衍射(XRD)进行表征。结果药载比为1∶11时,60 min内溶出度为62.01%。葫芦素B可能以无定形状态分散于载体中。结论该方法简便可行,葫芦素B制成固体分散体后体外溶出度明显提高。
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| 关 键 词： | 葫芦素B 固体分散体 制备 溶剂法 |
Preparation of cucurbitacin B solid dispersions |
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| CHENG Jia-hui,WU Qian,LIU Xi-gang.Preparation of cucurbitacin B solid dispersions[J].Chinese Traditional Patent Medicine,2020(3):570-573. |
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| Authors: | CHENG Jia-hui WU Qian LIU Xi-gang |
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| Institution: | (Hebei Provincial Key Laboratory for Research and Development of Traditional Chinese Medicine,Institute of Chinese Mateia Medica,Chengde Medical University,Chengde 067000,China) |
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| Abstract: | AIM To prepare cucurbitacin B solid dispersions.METHODS For the solid dispersions prepared by solvent method, drug-carrier(PVP K30) ratio screened with dissolution rate as an evaluation index. Characterization was performed by scanning electron microscope(SEM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC) and X-ray diffraction(XRD).RESULTS The dissolution rate within 60 min was 62.01% at the drug-carrier ratio of 1∶11. Cucurbitacin B may be dispersed in carrier with an amorphous phase.CONCLUSION Cucurbitacin B demonstrated obviously enhanced in vitro dissolution rate after being preparaed into solid dispersions by this simple and feasible method. |
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| Keywords: | cucurbit B solid dispersions preparation solvent method |
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