| 妊娠期亚临床甲状腺功能减退应用左旋甲状腺素干预治疗的研究进展 |
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| 引用本文： | 张爽,冷俊宏.妊娠期亚临床甲状腺功能减退应用左旋甲状腺素干预治疗的研究进展[J].中国妇幼卫生杂志,2020(2):76-82. |
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| 作者姓名： | 张爽 冷俊宏 |
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| 作者单位： | 天津市妇女儿童保健中心项目办公室 |
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| 基金项目： | 天津市卫生行业重点攻关项目(15KG118);中国疾病预防控制中心妇幼保健中心母婴营养与健康研究项目(2019FYH012)。 |
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| 摘 要： | 亚临床甲状腺功能减退(甲减)是妊娠期常见的内分泌疾病,可能增加不良妊娠结局发生风险和危害子代发育,但目前对患有亚临床甲减的妊娠期妇女进行左旋甲状腺素药物干预能否消除亚临床甲减带来的健康损害,目前尚存争议,并且何种情况启动药物治疗、药物剂量如何调整,意见仍不一致。因此,有待更多科学严谨的大样本前瞻性研究结果,来不断补充临床证据,进一步细化妊娠期亚临床甲减的左旋甲状腺素治疗方案。
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| 关 键 词： | 亚临床甲状腺功能减退 妊娠期 药物干预 左旋甲状腺素(LT4) |
Research progress of levothyroxine in the treatment of subclinical hypothyroidism during pregnancy |
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| ZHANG Shuang,LENG Jun,Hong.Research progress of levothyroxine in the treatment of subclinical hypothyroidism during pregnancy[J].Chinese Journal of Women and Children Health,2020(2):76-82. |
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| Authors: | ZHANG Shuang LENG Jun Hong |
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| Institution: | (Project Office,Tianjin Women and Children’s Health Center,Tianjin 300070,China) |
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| Abstract: | Subclinical hypothyroidism is a common endocrine disease during pregnancy.It may increase the risk of adverse pregnancy outcome and dysplasia of the offspring.However,It is still controversial whether the diagnosis of subclinical hypothyroidism during pregnancy should be treated with levothyroxine.Moreover,what kind of circumstances need to start drug treatment,how to adjust the drug dose,there is still disagreement.Therefore,more scientific and rigorous and large sample of research results are needed to clinical practice and accurate treatment of subclinical hypothyroidism with levothyroxine. |
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| Keywords: | subclinical hypothyroidism pregnancy drug intervention levothyroxine LT4 |
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