加味葛根芩连汤联合常规治疗对重度湿热型溃疡性结肠炎患者的临床疗效

目的考察加味葛根芩连汤联合常规治疗对重度湿热型溃疡性结肠炎患者的临床疗效。方法82例患者随机分为对照组和观察组,每组41例,对照组给予常规治疗(美沙拉嗪、氢化可的松琥珀酸钠),观察组在对照组基础上加用加味葛根芩连汤,疗程4周。检测症状评分、中医证候疗效、肠镜Baron评分、膜屏障功能指标(HIF?1α、DAO、D?LA)、血清促炎因子(IL?2、IL?6、TNF?α、IFN?γ、CRP)、血清抗炎因子(IL?4、IL?10、IL?13)、免疫功能指标(CD3+、CD4+、CD8+、CD4+/CD8+、NK细胞)、凝血功能指标(FIB、APTT、PLT)、不良反应发生率变化。结果观察组总有效率较对照组升高(P<0.05)。治疗后,观察组症状评分、肠镜Baron评分、膜屏障功能指标、血清促炎因子、CD8+、FIB、PLT、不良反应发生率较对照组降低(P<0.05),血清抗炎因子、CD3+、CD4+、CD4+/CD8+、NK细胞、APTT升高(P<0.05)。结论加味葛根芩连汤联合常规治疗能有效缓解重度湿热型溃疡性结肠炎患者临床症状,保护肠黏膜,降低不良反应,其机制可能与抑制促炎因子分泌、促进抗炎因子分泌、激活免疫功能、改善凝血功能有关。

Clinical effects of Supplemented Gegen Qinlian Decoction combined with routine treatment on patients with severe ulcerative colitis due to Damp-heat Pattern

AIM To investigate the clinical effects of Supplemented Gegen Qinlian Decoction combined with routine treatment on patients with severe ulcerative colitis due to Damp?heat Pattern.METHODS Eighty?two pa?tients were randomly assigned into control group(41 cases)for 4?week intervention of routine treatment(mesalazin,hydrocortisone sodium succinate),and observation group(41 cases)for 4?week intervention of both Supplemented Gegen Qinlian Decoction and routine treatment.The changes in symptom score,TCM syndrome effi?cacy,enteroscopic Baron score,membrane barrier function indices(HIF?1α,DAO,D?LA),serum pro?inflamma?tory factors(IL?2,IL?6,TNF?α,IFN?γ,CRP),serum anti?inflammatory factors(IL?4,IL?10,IL?13),immune function indices(CD3+,CD4+,CD8+,CD4+/CD8+,NK cells),coagulation function indices(FIB,APTT,PLT)and occurrence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the observation group displayed lower symptom score,enteroscopic Baron score,membrane barrier function indices,serum pro?inflammatory factors,CD8+,FIB,PLT and the occurrence of adverse reactions than the control group(P<0.05),along with higher serum anti?inflammatory factors,CD3+,CD4+,CD4+/CD8+,NK cells and APTT(P<0.05).CONCLUSION For the patients with severe ulcerative colitis due to Damp?heat Pattern,Supplemented Gegen Qinlian Decoction combined with routine treatment can effectively relieve clinical symptoms,protect intestinal mucosa and reduce ad?verse reactions,whose mechanisms may contribute to the inhibition of pro?inflammatory factor secretion,promotion of anti?inflammatory factor secretion,activation of immune functions and improvement of blood coagulation func?tions.