先天性免疫在钙化性主动脉瓣疾病中的作用

钙化性主动脉瓣疾病(CAVD)是影响心脏瓣膜的最常见疾病,其特征是主动脉瓣瓣小叶的增厚、纤维化和矿化,目前尚无有效的药物治疗。主动脉瓣钙化是一个复杂的、多因素影响的过程,包括瓣膜炎症、纤维化、钙化以及瓣膜增厚和心流出道阻塞。CAVD的确切病理生理机制尚不完全清楚,但许多研究表明先天免疫细胞在主动脉瓣钙化的发展中起关键作用。该综述主要阐述目前关于先天性免疫细胞在CAVD发展中的作用。

The role of innate immunity in calcific aortic valve disease

Calcific aortic valve disease (CAVD) is the most common disease affecting the heart valves, characterized by thickening, fibrosis, and mineralization of the aortic valve leaflets. Currently, there is no effective pharmacological treatment. Aortic valve calcification is a complex and multifactorial process involving valve inflammation, fibrosis, calcification, valve thickening and outflow tract obstruction. The exact pathophysiological mechanisms of CAVD are not fully understood, but many studies have suggested that innate immune cells play a key role in the development of aortic valve calcification. This review focuses on the current role of innate immune cells in the development of CAVD.